Table 2 CD6 genotype and diet effects in female mice
From: CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice
Phenotype | Chow diet | Western type diet | Diet effect | Genotype | Interaction | ||||
|---|---|---|---|---|---|---|---|---|---|
K0 | DK0 | T-test | K0 | DK0 | T-test | P value | P value | P value | |
Female mice | |||||||||
 Body weight (g) | 23.9 ± 2.5 (16) | 23.4 ± 2.9 (10) | N.S | 28.4 ± 5.2 (5) | 25.9 ± 3.5 (10) | N.S | 0.003 | N.S | N.S |
 Cholesterol (mg/dl) | 1064 ± 159.8 (13) | 1127 ± 240.9 (7) | N.S | 2338 ± 332.4 (5) | 2040 ± 473.7 (10) | N.S | < 0.0001 | N.S | N.S |
 HDL-C (mg/dl) | 56.6 ± 14.4 (10) | 53.8 ± 16.2 (7) | N.S | 40.5 ± 27.6 (3) | 44.2 ± 24.0 (7) | N.S | N.S | N.S | N.S |
 IgM (μg/ml) | 56.8 ± 47.4 (14) | 65.4 ± 34.1 (10) | N.S | 74.63 ± 21 (5) | 63.8 ± 24.4 (9) | N.S | N.S | N.S | N.S |
 Pc-IgM (OD read) | 0.31 ± 0.2 (14) | 0.18 ± 0.13 (10) | N.S | 0.54 ± 0.25 (5) | 0.85 ± 0.46 (10) | N.S | < 0.0001 | N.S | 0.032 |
 B1a cells (% of total cells) | 3.16 ± 0.58 (7) | 2.49 ± 1.23 (6) | N.S | 1.97 ± 0.54 (4) | 1.29 ± 0.45 (7) | 0.049 | 0.0013 | 0.048 | N.S |
 Lesion area (μm2) | 129,119 ± 59,493 (13) | 185,825 ± 108,327 (10) | N.S | 596,416 ± 233,19 9(5) | 466,142 ± 165,955 (9) | N.S | < 0.0001 | N.S | 0.026 |