Table 3 Association of CK 5/6 expression with clinicopathologic features of triple negative breast cancer
n (%) | P-value | ||||
|---|---|---|---|---|---|
No loss of expression (n = 94) | Complete loss of expression (n = 7) | Focal loss of expression (n = 49) | Total (n = 150) | ||
Age groups (years) | |||||
≤ 30 | 1 (1.1) | 1 (14.3) | 3 (6.1) | 5 (3.3) | 0.061 |
31–50 | 49 (52.1) | 4 (57.1) | 31 (63.3) | 84 (56) | |
> 50 | 44 (46.8) | 2 (28.6) | 15 (30.6) | 61 (40.7) | |
Tumor stage | |||||
T1 | 20 (21.3) | 2 (28.6) | 4 (8.2) | 26 (17.3) | 0.227 |
T2 | 47 (50) | 4 (57.1) | 28 (57.1) | 79 (52.7) | |
T3/T4 | 27 (28.7) | 1 (14.3) | 17 (34.7) | 45 (30) | |
ki67 index groups (%) | |||||
≤ 15 | 8 (8.5) | 2 (28.6) | 7 (14.3) | 17 (11.3) | 0.495 |
16–24 | 6 (6.4) | 0 (0) | 2 (4.1) | 8 (5.3) | |
25–44 | 32 (34) | 1 (14.3) | 12 (24.5) | 45 (30) | |
> 44 | 48 (51.1) | 4 (57.1) | 28 (57.1) | 80 (53.3) | |
Nodal status | |||||
Positive | 40 (42.6) | 4 (57.1) | 20 (40.8) | 64 (42.7) | 0.715 |
Negative | 54 (57.4) | 3 (42.9) | 29 (59.2) | 86 (57.3) | |
Nodal stage | |||||
No | 55 (58.5) | 3 (42.9) | 30 (61.2) | 88 (58.7) | 0.152 |
N1 | 16 (17) | 3 (42.9) | 11 (22.4) | 30 (20) | |
N2 | 7 (7.4) | 0 (0) | 6 (12.2) | 13 (8.7) | |
N3 | 16 (17) | 1 (14.3) | 2 (4.1) | 19 (12.7) | |
Histological subtypes | |||||
IDC | 83 (88.3) | 6 (85.7) | 38 (77.6) | 127 (84.7) | 0.138 |
Papillary | 5 (5.3) | 0 (0) | 1 (2) | 6(4) | |
Medullary | 1 (1.1) | 0 (0) | 0 (0) | 1 (0.7) | |
Metaplastic | 4 (4.3) | 1 (14.3) | 9 (18.4) | 14 (9.3) | |
Mixed | 1 (1.1) | 0 (0) | 1 (2) | 2 (1.3) | |
Tumor grade | |||||
Grade-I | 1 (1.1) | 0 (0) | 0 (0) | 1 (0.7) | 0.437 |
Grade-II | 15 (16) | 0 (0) | 4 (8.2) | 19 (12.7) | |
Grade-III | 78 (83) | 7 (100) | 45 (91.8) | 130 (86.7) | |
Lymphocytic infiltration | |||||
Absent | 9 (9.6) | 0 (0) | 6 (12.2) | 15 (10) | 0.585 |
Moderate | 72 (76.6) | 5 (71.4) | 33 (67.3) | 110 (73.3) | |
Severe | 13 (13.8) | 2 (28.6) | 10 (20.4) | 25 (16.7) | |
Lymphovascular invasion | |||||
Present | 26 (27.7) | 2 (28.6) | 8 (16.3) | 36 (24) | 0.261 |
Absent | 68 (72.3) | 5 (71.4) | 41 (83.7) | 114 (76) | |
Dermal lymphatic invasion | |||||
Present | 7 (7.4) | 0 (0) | 3 (6.1) | 10 (6.7) | 1.000 |
Absent | 87 (92.6) | 7 (100) | 46 (93.9) | 140 (93.3) | |
Type of surgery | |||||
Modified radical mastectomy | 59 (62.8) | 4 (57.1) | 31 (63.3) | 94 (62.7) | 0.806 |
Simple mastectomy with sentinel lymph node dissection | 25 (26.6) | 2 (28.6) | 15 (30.6) | 42 (28) | |
Wide local excision | 10 (10.6) | 1 (14.3) | 3 (6.1) | 14 (9.3) | |
Necrosis | |||||
Absent | 14 (14.9) | 1 (14.3) | 6 (12.2) | 21 (14) | 0.459 |
Moderate | 58 (61.7) | 5 (71.4) | 27 (55.1) | 90 (60) | |
Severe | 22 (23.4) | 1 (14.3) | 16 (32.7) | 39 (26) | |
Fibrosis | |||||
Mild | 22 (23.4) | 2 (28.6) | 18 (36.7) | 42 (28) | 0.101 |
Moderate | 58 (61.7) | 5 (71.4) | 25 (51) | 88 (58.7) | |
Severe | 14 (14.9) | 0 (0) | 6 (12.2) | 20 (13.3) | |
Insitu component | |||||
Present | 42 (44.7) | 3 (42.9) | 13 (26.5) | 58 (38.7) | 0.588 |
Absent | 52 (55.3) | 4 (57.1) | 36 (73.5) | 92 (61.3) | |
Pagetoid spread | |||||
Present | 2 (2.1) | 0 (0) | 0 (0) | 2 (1.3) | 0.078 |
Absent | 92 (97.9) | 7 (100) | 49 (100) | 148 (98.7) | |
Perinodal extension | |||||
Present | 24 (25.5) | 1 (14.3) | 5 (10.2) | 30 (20) | 0.614 |
Absent | 70 (74.5) | 6 (85.7) | 44 (89.8) | 120 (80) | |