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Table 3 Association of CK 5/6 expression with clinicopathologic features of triple negative breast cancer

From: Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population

  n (%) P-value
No loss of expression (n = 94) Complete loss of expression (n = 7) Focal loss of expression (n = 49) Total (n = 150)
Age groups (years)
 ≤ 30 1 (1.1) 1 (14.3) 3 (6.1) 5 (3.3) 0.061
 31–50 49 (52.1) 4 (57.1) 31 (63.3) 84 (56)
 > 50 44 (46.8) 2 (28.6) 15 (30.6) 61 (40.7)
Tumor stage
 T1 20 (21.3) 2 (28.6) 4 (8.2) 26 (17.3) 0.227
 T2 47 (50) 4 (57.1) 28 (57.1) 79 (52.7)
 T3/T4 27 (28.7) 1 (14.3) 17 (34.7) 45 (30)
ki67 index groups (%)
 ≤ 15 8 (8.5) 2 (28.6) 7 (14.3) 17 (11.3) 0.495
 16–24 6 (6.4) 0 (0) 2 (4.1) 8 (5.3)
 25–44 32 (34) 1 (14.3) 12 (24.5) 45 (30)
 > 44 48 (51.1) 4 (57.1) 28 (57.1) 80 (53.3)
Nodal status
 Positive 40 (42.6) 4 (57.1) 20 (40.8) 64 (42.7) 0.715
 Negative 54 (57.4) 3 (42.9) 29 (59.2) 86 (57.3)
Nodal stage
 No 55 (58.5) 3 (42.9) 30 (61.2) 88 (58.7) 0.152
 N1 16 (17) 3 (42.9) 11 (22.4) 30 (20)
 N2 7 (7.4) 0 (0) 6 (12.2) 13 (8.7)
 N3 16 (17) 1 (14.3) 2 (4.1) 19 (12.7)
Histological subtypes
 IDC 83 (88.3) 6 (85.7) 38 (77.6) 127 (84.7) 0.138
 Papillary 5 (5.3) 0 (0) 1 (2) 6(4)
 Medullary 1 (1.1) 0 (0) 0 (0) 1 (0.7)
 Metaplastic 4 (4.3) 1 (14.3) 9 (18.4) 14 (9.3)
 Mixed 1 (1.1) 0 (0) 1 (2) 2 (1.3)
Tumor grade
 Grade-I 1 (1.1) 0 (0) 0 (0) 1 (0.7) 0.437
 Grade-II 15 (16) 0 (0) 4 (8.2) 19 (12.7)
 Grade-III 78 (83) 7 (100) 45 (91.8) 130 (86.7)
Lymphocytic infiltration
 Absent 9 (9.6) 0 (0) 6 (12.2) 15 (10) 0.585
 Moderate 72 (76.6) 5 (71.4) 33 (67.3) 110 (73.3)
 Severe 13 (13.8) 2 (28.6) 10 (20.4) 25 (16.7)
Lymphovascular invasion
 Present 26 (27.7) 2 (28.6) 8 (16.3) 36 (24) 0.261
 Absent 68 (72.3) 5 (71.4) 41 (83.7) 114 (76)
Dermal lymphatic invasion
 Present 7 (7.4) 0 (0) 3 (6.1) 10 (6.7) 1.000
 Absent 87 (92.6) 7 (100) 46 (93.9) 140 (93.3)
Type of surgery
 Modified radical mastectomy 59 (62.8) 4 (57.1) 31 (63.3) 94 (62.7) 0.806
 Simple mastectomy with sentinel lymph node dissection 25 (26.6) 2 (28.6) 15 (30.6) 42 (28)
 Wide local excision 10 (10.6) 1 (14.3) 3 (6.1) 14 (9.3)
Necrosis
 Absent 14 (14.9) 1 (14.3) 6 (12.2) 21 (14) 0.459
 Moderate 58 (61.7) 5 (71.4) 27 (55.1) 90 (60)
 Severe 22 (23.4) 1 (14.3) 16 (32.7) 39 (26)
Fibrosis
 Mild 22 (23.4) 2 (28.6) 18 (36.7) 42 (28) 0.101
 Moderate 58 (61.7) 5 (71.4) 25 (51) 88 (58.7)
 Severe 14 (14.9) 0 (0) 6 (12.2) 20 (13.3)
Insitu component
 Present 42 (44.7) 3 (42.9) 13 (26.5) 58 (38.7) 0.588
 Absent 52 (55.3) 4 (57.1) 36 (73.5) 92 (61.3)
Pagetoid spread
 Present 2 (2.1) 0 (0) 0 (0) 2 (1.3) 0.078
 Absent 92 (97.9) 7 (100) 49 (100) 148 (98.7)
Perinodal extension
 Present 24 (25.5) 1 (14.3) 5 (10.2) 30 (20) 0.614
 Absent 70 (74.5) 6 (85.7) 44 (89.8) 120 (80)
  1. Chi Square test applied
  2. P-value ≤ 0.05, considered as significant