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Table 1 Activity of cyclic peptides against M. tuberculosis

From: Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

Compound number Structure Synonym MIC90
1 MSD-045 2.3 ± 0.5
2 MSD-524 2.8 ± 0.8
3 MSD-099 8.9 ± 1.8
4 MSD-135 7.3 ± 1.9
5 MSD-2980 8.2 ± 1.2
6 MSD-695 > 20
7 MSD-408 > 20
8 MSD-196 > 20
9 MSD-818 > 20
10 MSD-109 > 20
11 MSD-810 > 20
12 MSD-008 > 20
13 MSD-369 > 20
14 MSD-229 > 20
15 MSD-049 > 20
16 MSD-064 > 20
  1. MIC90 were determined against aerobically-cultured M. tuberculosis in liquid culture after 5 days of growth [5]. Growth inhibition curves were plotted using the Levenberg–Marquardt algorithm and the concentration that resulted in 90% inhibition of growth was determined (MIC90). MIC90 were determined a minimum of two times for active compounds. Data are average ± standard deviation