Compound number | Structure | Synonym | MIC90 |
---|
1
|
| MSD-045 | 2.3 ± 0.5 |
2
|
| MSD-524 | 2.8 ± 0.8 |
3
|
| MSD-099 | 8.9 ± 1.8 |
4
|
| MSD-135 | 7.3 ± 1.9 |
5
|
| MSD-2980 | 8.2 ± 1.2 |
6
|
| MSD-695 | > 20 |
7
|
| MSD-408 | > 20 |
8
|
| MSD-196 | > 20 |
9
|
| MSD-818 | > 20 |
10
|
| MSD-109 | > 20 |
11
|
| MSD-810 | > 20 |
12
|
| MSD-008 | > 20 |
13
|
| MSD-369 | > 20 |
14
|
| MSD-229 | > 20 |
15
|
| MSD-049 | > 20 |
16
|
| MSD-064 | > 20 |
- MIC90 were determined against aerobically-cultured M. tuberculosis in liquid culture after 5 days of growth [5]. Growth inhibition curves were plotted using the Levenberg–Marquardt algorithm and the concentration that resulted in 90% inhibition of growth was determined (MIC90). MIC90 were determined a minimum of two times for active compounds. Data are average ± standard deviation