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Table 2 Effect of Duloxetine treatment on concentration of NO, nitrite, arginase and SOD activity from Ehrlich tumor-bearing mice

From: Tumor growth activity of duloxetine in Ehrlich carcinoma in mice

  D5 D30 C p
Spleen NO (mM) 3.5 (2.5–4.5) 6.4 (3.1–10.0) 1.6 (0.8–4.0) 0.080
Ascites NO (mM) 13.9 (11.4–16.7) 12.7 (7.0–19.6) 12.6 (11.2–18.3) 0.801
Ascites nitrite (mM) 5.1 (4.9–7.1) 5.0 (4.6–5.6) 5.4 (4.9–5.6) 0.499
Ascites arginase (unit/L) 48.6 (45.8–51.4) 52.9 (45.5–56.7) 48.1 (36.7–67.7) 0.690
Ascites SOD (% activity) 92.5 (88.9–96.9)* 91.6 (87.7–94.2)* 87.6 (86.5–88.4) 0.050
  1. The animals were treated with duloxetine (5 and 30 mg/kg) or saline (control) orally from days 2 to 8 after intraperitoneal inoculation of the 2 × 106 Ehrlich tumor cells (median/IQR)
  2. D5 5 mg/kg, D30 duloxetine 30 mg/kg; S saline, NO nitric oxide, SOD superoxide dismutase, Kruskal–Wallis test, IQR interquartile
  3. *Significant