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Table 2 Genetic models and genotypes distribution in patients and controls

From: The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease

Gene
SNP
Group 1/2 Genotype, N (%) Dominant model
Genotype 11 + 12 vs. 22
Recessive model
Genotype 11 vs. 12 + 22
AA AG GG OR (95% CI) P-value OR (95% CI) P-value
PTPN22 rs2476601 Controls A/G 1 (0.32) 9 (2.89) 301 (96.78)  
IBD 1 (0.51) 8 (4.10) 186 (95.38) 1.45 [0.58–3.65] 0.42 1.59 [0.09–25.7] 0.74
CD 0 (0.00) 5 (3.70) 130 (96.30) 1.15 [0.38–3.45] 0.79 NA NA
UC 1 (1.69) 3 (5.08) 56 (94.91) 2.15 [0.65–7.09] 0.20 5.25 [0.32–85.18] 0.24
  1. No association was seen with PTPN22 SNP under dominant model AA + AG vs. GG (11 + 12 vs. 22) or recessive AA vs. AG + GG (11 vs. 12 + 22) either for the IBD group or when dividing into CD and UC groups
  2. PTPN22 protein tyrosine phosphatase non-receptor type 22, SNP Single nucleotide polymorphism, IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, OR odds ratios