From: The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease
Gene SNP | Group | 1/2 | Genotype, N (%) | Dominant model Genotype 11 + 12 vs. 22 | Recessive model Genotype 11 vs. 12 + 22 | ||||
---|---|---|---|---|---|---|---|---|---|
AA | AG | GG | OR (95% CI) | P-value | OR (95% CI) | P-value | |||
PTPN22 rs2476601 | Controls | A/G | 1 (0.32) | 9 (2.89) | 301 (96.78) | ||||
IBD | 1 (0.51) | 8 (4.10) | 186 (95.38) | 1.45 [0.58–3.65] | 0.42 | 1.59 [0.09–25.7] | 0.74 | ||
CD | 0 (0.00) | 5 (3.70) | 130 (96.30) | 1.15 [0.38–3.45] | 0.79 | NA | NA | ||
UC | 1 (1.69) | 3 (5.08) | 56 (94.91) | 2.15 [0.65–7.09] | 0.20 | 5.25 [0.32–85.18] | 0.24 |