Skip to main content

Advertisement

Table 1 Effects of TAK-442 on plasma hemostatic parameters in a modified rabbit arteriovenous shunt thrombosis model

From: Anti-thrombotic effect of a factor Xa inhibitor TAK-442 in a rabbit model of arteriovenous shunt thrombosis stimulated with tissue factor

  Control (basal value) TAK-442 (μg/kg)
0 (vehicle only) 18.75 37.5 75
Anti-FXa activity (% inhibition) 13 ± 2.5 12 ± 1.8 17 ± 3.8 26 ± 3.6 45 ± 4.7
PT (% of control) 100 ± 0.62 102 ± 2.2 105 ± 2.0 109 ± 2.5 116 ± 3.7
APTT (% of control) 100 ± 3.3 106 ± 6.5 119 ± 5.4 121 ± 5.9 129 ± 7.5
  1. In a rabbit model of arteriovenous shunt thrombosis stimulated with tissue factor, plasma anti-FXa activity and clotting times were measured. Blood was collected for 5 min during each thrombus formation. The drug was administered as a bolus (two-thirds of total dose) followed by constant intravenous infusion (one-third of total dose) for 30 min prior to shunt placement. Data are expressed as mean ± standard error of the mean; n = 4 animals per treatment group