Anti-thrombotic effect of a factor Xa inhibitor TAK-442 in a rabbit model of arteriovenous shunt thrombosis stimulated with tissue factor

Table 1 Effects of TAK-442 on plasma hemostatic parameters in a modified rabbit arteriovenous shunt thrombosis model

	Control (basal value)	TAK-442 (μg/kg)
	Control (basal value)	0 (vehicle only)	18.75	37.5	75
Anti-FXa activity (% inhibition)	13 ± 2.5	12 ± 1.8	17 ± 3.8	26 ± 3.6	45 ± 4.7
PT (% of control)	100 ± 0.62	102 ± 2.2	105 ± 2.0	109 ± 2.5	116 ± 3.7
APTT (% of control)	100 ± 3.3	106 ± 6.5	119 ± 5.4	121 ± 5.9	129 ± 7.5

In a rabbit model of arteriovenous shunt thrombosis stimulated with tissue factor, plasma anti-FXa activity and clotting times were measured. Blood was collected for 5 min during each thrombus formation. The drug was administered as a bolus (two-thirds of total dose) followed by constant intravenous infusion (one-third of total dose) for 30 min prior to shunt placement. Data are expressed as mean ± standard error of the mean; n = 4 animals per treatment group

ISSN: 1756-0500