Fig. 1

Frequency of inhibitory receptor expressing T cells in matched blood and effusion samples from malignant mesothelioma patients. a PD-1, Tim-3 and LAG-3 expressing CD4⁺ (top row) and CD8⁺ (bottom row) T cells plotted as a frequency of total CD3⁺CD4⁺ or CD3⁺CD8⁺ T cells respectively. Each point and connecting line represents a paired patient sample, and the star on each graph represents the single patient sample that underwent TCR sequencing. All paired samples were compared using a Wilcoxon’s test. b Frequency of PD-1, Tim-3 and LAG-3 expressing CD4⁺ and CD8⁺ T cells from effusion samples. Matched samples were compared with a Friedman test, corrected for multiple comparisons using Dunn’s test