Alpha 1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease patients: is systematic screening necessary?

Table 1 Demographic and spirometric data from patients included in the study

	All COPD patients n = 551	AAT deficiency n = 40	Pi*ZZ n = 11	p-value
Male: female	283:268	21:19	4:7	–
Age (mean ± SD)	65.2 ± 14.0	63.2 ± 10.2	60.0 ± 7.3	0.19
Smoking (pack-years)	46.5 ± 41.2	34.7 ± 36.9	4.1 ± 11.2	0.02
FEV₁ (% predicted)	50.2 ± 20.6	49.1 ± 20.4	37.7 ± 7.9	0.22
FVC (% predicted)	76.3 ± 22.3	79.4 ± 19.2	78.8 ± 21.4	0.75
FEV₁/FVC (%)	50.7 ± 13.6	49.0 ± 13.6	41.9 ± 14.6	0.18

The difference among the three groups was analyzed by ANOVA followed by Turkey’s multiple comparison test
COPD chronic obstructive pulmonary disease, SD standard deviation, FEV1 forced expiratory volume at first second, FVC forced vital capacity

ISSN: 1756-0500