Fig. 1
Regular exposure to UVR did not modify body weight, weight gain, food intake or distance run by mature adult mice fed a high fat diet. Fourteen 25 week-old C57Bl/6J male mice were fed a vitamin D-deficient low fat diet for 4 weeks. From 29 weeks of age, mice were fed a high fat diet for a further 12 weeks. The shaved dorsal skin of these mice were treated twice a week with either: (1) sub-erythemal UVR (1 kJ/m2 UVB); or, (2) were mock irradiated (Mock UVR). Mice were treated for 12 weeks with the mock or UVR treatments and fed a high fat diet until 41 weeks of age. There were 7 mice per treatment. nb. One mouse was euthanized from the UVR treatment due to the development of a severe dermatitis, which did not resolve. In a, is an overview of the experiment. In b, body weights at baseline and after 6 and 12 weeks, and, c body weight gain (as a % of baseline) after 6 and 12 weeks of being fed the high fat diet. In d, is food intake per day. In e, distance run was measured for the first 3 h immediately following a mock or UVR treatments after 5, 8, 9 and 11 weeks of feeding mice the high fat diet. Data is shown for n = 7 mock-irradiated and n = 6 UVR-exposed mice in b–d, and n = 4/treatment in e. All values are expressed as the mean +/± SEM, with (*) denoting significant differences between time points (p < 0.05)