Table 2 Mean difference (effect size) for device exposure (Accuhaler use versus MDI/s) on lung function, quality of life measures and 6MWT, including relevant interactions
Covariate | Dependent variable | ||||||||
|---|---|---|---|---|---|---|---|---|---|
FEV1 (%) | FVC (%) | RV (%) | MIP(%) | Impact score | Symptom score | Activity score | SGRQ total score | 6MWT (m) | |
Accuhaler (versus MDI/s) | 1.47 (0.1438) | 2.82 (− 0.2099) | − 2.60 (− 0.0825) | 8.10 (0.3656) | − 4.56 (− 0.3667) | − 0.90 (− 0.0653) | − 0.75 (− 0.0559) | − 2.46 (− 0.2189) | 8.3 (0.0907) |
P value | 0.53 | 0.45 | 0.77 | 0.31 | 0.24 | 0.86 | 0.89 | 0.52 | 0.74 |
Inhaler technique (adequate versus inadequate) | 2.95 (0.2945) | 6.00 (0.5203) | − 2.57 (− 0.0822) | 9.87 (0.4625) | − 5.87 (− 0.4643) | − 0.90 (− 0.0654) | − 1.60 (− 0.1195) | − 4.11 (− 0.3615) | 3.02 (0.0333) |
P value | 0.42 | 0.24 | 0.85 | 0.36 | 0.42 | 0.86 | 0.84 | 0.52 | 0.95 |
Accuhaler adequate inhaler technique | 2.63 (0.2556) | 3.87 (0.3183) | − 15.02 (− 0.4907) | 1.41 (0.0690) | − 6.38 (− 0.4897) | − 0.70 (− 0.0523) | − 4.72 (0.3125) | − 5.00 (− 0.4051) | − 9.07 (− 0.1004) |
P value | 0.67 | 0.58 | 0.46 | 0.93 | 0.60 | 0.96 | 0.69 | 0.68 | 0.91 |