Differential genome-wide DNA methylation patterns in childhood obesity

BMC Research Notes

Table 2 10 CpG sites (FDR < 0.01) whose DNA methylation levels were significantly different between obese and non-obese group

ID	UCSC_refgene_name	Mean_nonobese	SD non-obese	Mean_obese	SD obese	t	df	p.value	FDR	Mean difference (obese–nonobese)	Cohen’s d
cg16507569	COL11A2	0.840	0.164	0.515	0.012	9.972	26.332	<0.001	<0.001	− 0.324	2.208
cg27289463		0.264	0.090	0.432	0.029	− 7.710	21.432	<0.001	0.001	0.169	2.061
cg25013753	ARHGAP22	0.465	0.318	0.035	0.013	6.877	25.396	<0.001	0.001	− 0.430	1.508
cg19697575		0.596	0.366	0.103	0.065	6.354	28.996	<0.001	0.002	− 0.493	1.494
cg26935333		0.397	0.075	0.293	0.020	6.023	24.897	<0.001	0.007	− 0.104	1.539
cg14007688	DBH	0.577	0.290	0.898	0.011	− 5.620	25.354	<0.001	0.009	0.321	1.232
cg22459517	EPS8L1	0.631	0.194	0.851	0.014	− 5.680	26.244	<0.001	0.009	0.220	1.257
cg25813936	GNE	0.793	0.081	0.886	0.012	− 5.523	28.621	<0.001	0.009	0.093	1.268
cg00320354	TSPAN5	0.758	0.178	0.963	0.027	− 5.538	28.730	<0.001	0.009	0.204	1.276
cg08282428	RBM46	0.680	0.070	0.580	0.022	5.897	21.332	<0.001	0.009	− 0.100	1.578

COL11A2 collagen type XI alpha 2 chain, ARHGAP22 rho GTPase activating protein 22, DBH dopamine beta-hydroxylase, EPS8L1 EPS8 like 1, GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, TSPAN5 tetraspanin 5, RBM46 RNA binding motif protein 46

ISSN: 1756-0500