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Table 2 Summary of findings for 92 biomarkers before, and 30 and 120 min after a standardised meal

From: Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel

Variable Fasting (n = 22) 30 min after food intake (n = 21) 120 min after food intake (n = 22)
Alpha-taxilin 1.97 ± 0.37 1.84 ± 0.42 1.58 ± 0.47
Vascular endothelial growth factor A 9.72 ± 0.53 9.64 ± 0.56 9.64 ± 0.62
Carboxypeptidase E 2.43 ± 0.47 2.36 ± 0.43* 2.24 ± 0.62
Kallikrein-13 3.27 ± 0.39 3.20 ± 0.48 3.22 ± 0.42
Carcinoembryonic antigen-related cell adhesion molecule 1 6.75 ± 0.15 6.73 ± 0.15 6.73 ± 0.17
Mesothelin 4.61 ± 0.53 4.62 ± 0.54 4.67 ± 0.53
Tumor necrosis factor ligand superfamily member 13 7.19 ± 0.28 7.10 ± 0.28 7.10 ± 0.34
Pro-epidermal growth factor 10.74 ± 0.24 10.13 ± 0.63* 9.73 ± 0.70*
Tumor necrosis factor receptor superfamily member 6B 3.49 ± 0.49 3.51 ± 0.46 3.42 ± 0.72
Syndecan-1 6.24 ± 0.47 6.17 ± 0.50 6.23 ± 0.57
TGF-beta receptor type-2 6.58 ± 0.32 6.47 ± 0.30 6.53 ± 0.36
Interleukin-6 1.03 ± 1.16 1.01 ± 1.23 1.81 ± 1.20
CD48 antigen 6.07 ± 0.27 5.99 ± 0.26 6.03 ± 0.40
Secretory carrier-associated membrane protein 3 1.67 ± 0.57 1.25 ± 0.47 1.02 ± 0.36*
T-lymphocyte surface antigen Ly-9 4.58 ± 0.29 4.52 ± 0.28 4.58 ± 0.42
Interferon gamma receptor 1 3.52 ± 0.32 3.48 ± 0.33 3.50 ± 0.28
Integrin alpha-V 2.28 ± 0.25 2.27 ± 0.26 2.27 ± 0.20
TNF-related apoptosis-inducing ligand 6.83 ± 0.43 6.82 ± 0.40 6.86 ± 0.49
Kallikrein-11 4.95 ± 0.40 4.97 ± 0.38 4.77 ± 0.37
Glypican-1 3.83 ± 0.40 3.79 ± 0.38 3.82 ± 0.33
Tissue factor pathway inhibitor 2 6.36 ± 0.43 6.32 ± 0.40 6.46 ± 0.41
Kallikrein-8 6.27 ± 0.34 6.24 ± 0.34 5.98 ± 0.40
Vascular endothelial growth factor receptor 2 6.38 ± 0.18 6.34 ± 0.18 6.37 ± 0.20
Ly6/PLAUR domain-containing protein 3 3.59 ± 0.28 3.56 ± 0.30 3.57 ± 0.48
Podocalyxin 2.98 ± 0.19 2.99 ± 0.18 3.02 ± 0.18
Protein S100-A4 3.64 ± 0.41 3.63 ± 0.52 3.40 ± 0.49
Insulin-like growth factor 1 receptor 2.92 ± 0.29 2.83 ± 0.32 2.82 ± 0.33
Receptor tyrosine-protein kinase erbB-2 6.31 ± 0.24 6.26 ± 0.26 6.32 ± 0.38
Receptor tyrosine-protein kinase erbB-3 7.19 ± 0.24 7.15 ± 0.21 7.19 ± 0.24
Stem cell factor 8.76 ± 0.32 8.80 ± 0.28 8.79 ± 0.29
SPARC 5.88 ± 0.17 5.85 ± 0.18 5.83 ± 0.16
Granzyme H 2.43 ± 0.56 2.11 ± 0.55* 2.18 ± 0.76
Transforming growth factor alpha 2.78 ± 0.49 2.70 ± 0.58 2.60 ± 0.50
Furin 3.07 ± 0.36 2.96 ± 0.38 3.12 ± 0.41
Protein CYR61 4.27 ± 0.53 4.23 ± 0.51 4.33 ± 0.65
Kallikrein-14 5.46 ± 0.65 5.31 ± 0.67 5.19 ± 0.70
FAS-associated death domain protein 2.06 ± 0.77 1.66 ± 0.73 1.22 ± 0.52*
Methionine aminopeptidase 2 2.85 ± 0.87 2.79 ± 0.83* 2.44 ± 0.61*
Nectin-4 5.52 ± 0.35 5.40 ± 0.32* 5.25 ± 0.49
Tumor necrosis factor ligand superfamily member 6 8.72 ± 0.36 8.67 ± 0.37 8.74 ± 0.44
Ephrin type-A receptor 2 1.11 ± 0.30 1.08 ± 0.32 1.06 ± 0.31
Integrin beta-5 6.33 ± 0.25 6.27 ± 0.26 6.28 ± 0.28
Galectin-1 4.76 ± 0.21 4.76 ± 0.21 4.68 ± 0.31
Seizure 6-like protein 4.46 ± 0.24 4.46 ± 0.28 4.45 ± 0.29
Transmembrane glycoprotein NMB 5.38 ± 0.16 5.36 ± 0.19 5.37 ± 0.18
Carbonic anhydrase 9 1.66 ± 0.56 1.77 ± 0.55 1.69 ± 0.75
Melanoma-derived growth regulatory protein 9.32 ± 0.26 9.31 ± 0.26 9.26 ± 0.28
Cathepsin L2 2.80 ± 0.37 2.59 ± 0.30* 2.59 ± 0.44
CD27 antigen 7.52 ± 0.34 7.46 ± 0.34 7.50 ± 0.49
Xaa-Pro aminopeptidase 2 5.96 ± 0.47 5.90 ± 0.47 5.98 ± 0.53
Receptor tyrosine-protein kinase erbB-4 4.37 ± 0.23 4.31 ± 0.25 4.36 ± 0.34
Hepatocyte growth factor 6.15 ± 0.54 6.06 ± 0.50 6.05 ± 0.52
Disintegrin and metalloproteinase domain-containing protein 8 4.10 ± 0.33 4.00 ± 0.29 3.96 ± 0.39
5′-Nucleotidase 9.05 ± 0.31 8.95 ± 0.28 9.00 ± 0.34
Cyclin-dependent kinase inhibitor 1 0.52 ± 0.49 0.42 ± 0.48 0.21 ± 0.56
Delta-like protein 1 8.60 ± 0.31 8.57 ± 0.27 8.59 ± 0.34
Midkine 5.11 ± 0.48 4.82 ± 0.63 4.80 ± 0.72
Tyrosine-protein kinase ABL1 1.56 ± 0.68 1.31 ± 0.69 1.13 ± 0.69
Fibroblast growth factor-binding protein 1 6.21 ± 0.26 6.19 ± 0.34 6.10 ± 0.37
Toll-like receptor 3 4.68 ± 0.57 4.64 ± 0.62 4.68 ± 0.68
Tyrosine-protein kinase Lyn − 0.06 ± 0.19 − 0.15 ± 0.21 − 0.19 ± 0.25
Proto-oncogene tyrosine-protein kinase receptor Ret 4.30 ± 0.47 4.24 ± 0.45 4.29 ± 0.43
Vimentin 3.68 ± 0.37 3.49 ± 0.47 3.32 ± 0.49
Tumor necrosis factor receptor superfamily member 19 3.95 ± 0.41 3.90 ± 0.36 3.81 ± 0.54
Cornulin 5.44 ± 1.16 5.46 ± 1.18 5.51 ± 0.99
T-cell leukemia/lymphoma protein 1A 3.89 ± 0.82 3.78 ± 0.82 3.65 ± 0.90
CD160 antigen 4.61 ± 0.35 4.55 ± 0.28 4.51 ± 0.53
Tumor necrosis factor receptor superfamily member 4 2.57 ± 0.40 2.51 ± 0.36 2.51 ± 0.45
MHC class I polypeptide-related sequence A and B 2.60 ± 1.78 2.49 ± 1.80 2.56 ± 1.85
WNT1-inducible-signaling pathway protein 1 4.58 ± 0.60 4.48 ± 0.64 4.51 ± 0.59
VEGF-co regulated chemokine 1 1.69 ± 0.46 1.69 ± 0.51 1.70 ± 0.61
Pancreatic prohormone 2.39 ± 0.79 4.29 ± 0.91* 3.71 ± 1.22*
Protein S100-A11 2.73 ± 0.36 2.62 ± 0.36 2.56 ± 0.46
Amphiregulin 1.28 ± 0.46 1.26 ± 0.37 1.21 ± 0.41
Endothelial cell-specific molecule 1 7.99 ± 0.48 8.02 ± 0.47 8.09 ± 0.52
C-type lectin domain family 4 member K 2.29 ± 0.34 2.22 ± 0.30 2.24 ± 0.45
ICOS ligand 6.13 ± 0.38 6.00 ± 0.46 6.11 ± 0.39
WAP four-disulfide core domain protein 2 6.38 ± 0.32 6.36 ± 0.30 6.32 ± 0.40
C-X-C motif chemokine 13 8.26 ± 0.57 8.20 ± 0.51 8.32 ± 0.60
Mothers against decapentaplegic homolog 5 1.76 ± 0.46 1.80 ± 0.55 1.78 ± 0.56
A disintegrin and metalloproteinase with thrombospondin motifs 15 0.35 ± 0.43 0.45 ± 0.42 0.35 ± 0.52
CD70 antigen 2.84 ± 0.35 2.87 ± 0.38 2.90 ± 0.55
R-spondin-3 − 0.20 ± 0.36 − 0.28 ± 0.36 − 0.07 ± 0.53
Folate receptor gamma 6.51 ± 1.69 6.48 ± 1.75 6.44 ± 1.75
Carcinoembryonic antigen-related cell adhesion molecule 5 1.45 ± 0.62 1.38 ± 0.70 1.48 ± 0.64
Vascular endothelial growth factor receptor 3 5.56 ± 0.25 5.54 ± 0.25 5.51 ± 0.31
Mucin-16 3.07 ± 0.85 3.12 ± 0.78 3.14 ± 0.92
Wnt inhibitory factor 1 5.23 ± 0.47 5.12 ± 0.42 5.16 ± 0.50
Granzyme B 1.91 ± 0.81 1.75 ± 0.86 1.85 ± 0.90
Fc receptor-like B − 0.39 ± 0.55 − 0.33 ± 0.55 − 0.38 ± 0.57
Annexin A1 1.93 ± 0.43 1.82 ± 0.47 1.69 ± 0.50
Folate receptor alpha 5.83 ± 0.29 5.79 ± 0.28 5.81 ± 0.43
  1. All values are in arbitrary units (Mean ± SD)
  2. * Indicates significant difference (P < 0.001), compared to fasting values