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Table 2 Summary of findings for 92 biomarkers before, and 30 and 120 min after a standardised meal

From: Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel

Variable

Fasting (n = 22)

30 min after food intake (n = 21)

120 min after food intake (n = 22)

Alpha-taxilin

1.97 ± 0.37

1.84 ± 0.42

1.58 ± 0.47

Vascular endothelial growth factor A

9.72 ± 0.53

9.64 ± 0.56

9.64 ± 0.62

Carboxypeptidase E

2.43 ± 0.47

2.36 ± 0.43*

2.24 ± 0.62

Kallikrein-13

3.27 ± 0.39

3.20 ± 0.48

3.22 ± 0.42

Carcinoembryonic antigen-related cell adhesion molecule 1

6.75 ± 0.15

6.73 ± 0.15

6.73 ± 0.17

Mesothelin

4.61 ± 0.53

4.62 ± 0.54

4.67 ± 0.53

Tumor necrosis factor ligand superfamily member 13

7.19 ± 0.28

7.10 ± 0.28

7.10 ± 0.34

Pro-epidermal growth factor

10.74 ± 0.24

10.13 ± 0.63*

9.73 ± 0.70*

Tumor necrosis factor receptor superfamily member 6B

3.49 ± 0.49

3.51 ± 0.46

3.42 ± 0.72

Syndecan-1

6.24 ± 0.47

6.17 ± 0.50

6.23 ± 0.57

TGF-beta receptor type-2

6.58 ± 0.32

6.47 ± 0.30

6.53 ± 0.36

Interleukin-6

1.03 ± 1.16

1.01 ± 1.23

1.81 ± 1.20

CD48 antigen

6.07 ± 0.27

5.99 ± 0.26

6.03 ± 0.40

Secretory carrier-associated membrane protein 3

1.67 ± 0.57

1.25 ± 0.47

1.02 ± 0.36*

T-lymphocyte surface antigen Ly-9

4.58 ± 0.29

4.52 ± 0.28

4.58 ± 0.42

Interferon gamma receptor 1

3.52 ± 0.32

3.48 ± 0.33

3.50 ± 0.28

Integrin alpha-V

2.28 ± 0.25

2.27 ± 0.26

2.27 ± 0.20

TNF-related apoptosis-inducing ligand

6.83 ± 0.43

6.82 ± 0.40

6.86 ± 0.49

Kallikrein-11

4.95 ± 0.40

4.97 ± 0.38

4.77 ± 0.37

Glypican-1

3.83 ± 0.40

3.79 ± 0.38

3.82 ± 0.33

Tissue factor pathway inhibitor 2

6.36 ± 0.43

6.32 ± 0.40

6.46 ± 0.41

Kallikrein-8

6.27 ± 0.34

6.24 ± 0.34

5.98 ± 0.40

Vascular endothelial growth factor receptor 2

6.38 ± 0.18

6.34 ± 0.18

6.37 ± 0.20

Ly6/PLAUR domain-containing protein 3

3.59 ± 0.28

3.56 ± 0.30

3.57 ± 0.48

Podocalyxin

2.98 ± 0.19

2.99 ± 0.18

3.02 ± 0.18

Protein S100-A4

3.64 ± 0.41

3.63 ± 0.52

3.40 ± 0.49

Insulin-like growth factor 1 receptor

2.92 ± 0.29

2.83 ± 0.32

2.82 ± 0.33

Receptor tyrosine-protein kinase erbB-2

6.31 ± 0.24

6.26 ± 0.26

6.32 ± 0.38

Receptor tyrosine-protein kinase erbB-3

7.19 ± 0.24

7.15 ± 0.21

7.19 ± 0.24

Stem cell factor

8.76 ± 0.32

8.80 ± 0.28

8.79 ± 0.29

SPARC

5.88 ± 0.17

5.85 ± 0.18

5.83 ± 0.16

Granzyme H

2.43 ± 0.56

2.11 ± 0.55*

2.18 ± 0.76

Transforming growth factor alpha

2.78 ± 0.49

2.70 ± 0.58

2.60 ± 0.50

Furin

3.07 ± 0.36

2.96 ± 0.38

3.12 ± 0.41

Protein CYR61

4.27 ± 0.53

4.23 ± 0.51

4.33 ± 0.65

Kallikrein-14

5.46 ± 0.65

5.31 ± 0.67

5.19 ± 0.70

FAS-associated death domain protein

2.06 ± 0.77

1.66 ± 0.73

1.22 ± 0.52*

Methionine aminopeptidase 2

2.85 ± 0.87

2.79 ± 0.83*

2.44 ± 0.61*

Nectin-4

5.52 ± 0.35

5.40 ± 0.32*

5.25 ± 0.49

Tumor necrosis factor ligand superfamily member 6

8.72 ± 0.36

8.67 ± 0.37

8.74 ± 0.44

Ephrin type-A receptor 2

1.11 ± 0.30

1.08 ± 0.32

1.06 ± 0.31

Integrin beta-5

6.33 ± 0.25

6.27 ± 0.26

6.28 ± 0.28

Galectin-1

4.76 ± 0.21

4.76 ± 0.21

4.68 ± 0.31

Seizure 6-like protein

4.46 ± 0.24

4.46 ± 0.28

4.45 ± 0.29

Transmembrane glycoprotein NMB

5.38 ± 0.16

5.36 ± 0.19

5.37 ± 0.18

Carbonic anhydrase 9

1.66 ± 0.56

1.77 ± 0.55

1.69 ± 0.75

Melanoma-derived growth regulatory protein

9.32 ± 0.26

9.31 ± 0.26

9.26 ± 0.28

Cathepsin L2

2.80 ± 0.37

2.59 ± 0.30*

2.59 ± 0.44

CD27 antigen

7.52 ± 0.34

7.46 ± 0.34

7.50 ± 0.49

Xaa-Pro aminopeptidase 2

5.96 ± 0.47

5.90 ± 0.47

5.98 ± 0.53

Receptor tyrosine-protein kinase erbB-4

4.37 ± 0.23

4.31 ± 0.25

4.36 ± 0.34

Hepatocyte growth factor

6.15 ± 0.54

6.06 ± 0.50

6.05 ± 0.52

Disintegrin and metalloproteinase domain-containing protein 8

4.10 ± 0.33

4.00 ± 0.29

3.96 ± 0.39

5′-Nucleotidase

9.05 ± 0.31

8.95 ± 0.28

9.00 ± 0.34

Cyclin-dependent kinase inhibitor 1

0.52 ± 0.49

0.42 ± 0.48

0.21 ± 0.56

Delta-like protein 1

8.60 ± 0.31

8.57 ± 0.27

8.59 ± 0.34

Midkine

5.11 ± 0.48

4.82 ± 0.63

4.80 ± 0.72

Tyrosine-protein kinase ABL1

1.56 ± 0.68

1.31 ± 0.69

1.13 ± 0.69

Fibroblast growth factor-binding protein 1

6.21 ± 0.26

6.19 ± 0.34

6.10 ± 0.37

Toll-like receptor 3

4.68 ± 0.57

4.64 ± 0.62

4.68 ± 0.68

Tyrosine-protein kinase Lyn

− 0.06 ± 0.19

− 0.15 ± 0.21

− 0.19 ± 0.25

Proto-oncogene tyrosine-protein kinase receptor Ret

4.30 ± 0.47

4.24 ± 0.45

4.29 ± 0.43

Vimentin

3.68 ± 0.37

3.49 ± 0.47

3.32 ± 0.49

Tumor necrosis factor receptor superfamily member 19

3.95 ± 0.41

3.90 ± 0.36

3.81 ± 0.54

Cornulin

5.44 ± 1.16

5.46 ± 1.18

5.51 ± 0.99

T-cell leukemia/lymphoma protein 1A

3.89 ± 0.82

3.78 ± 0.82

3.65 ± 0.90

CD160 antigen

4.61 ± 0.35

4.55 ± 0.28

4.51 ± 0.53

Tumor necrosis factor receptor superfamily member 4

2.57 ± 0.40

2.51 ± 0.36

2.51 ± 0.45

MHC class I polypeptide-related sequence A and B

2.60 ± 1.78

2.49 ± 1.80

2.56 ± 1.85

WNT1-inducible-signaling pathway protein 1

4.58 ± 0.60

4.48 ± 0.64

4.51 ± 0.59

VEGF-co regulated chemokine 1

1.69 ± 0.46

1.69 ± 0.51

1.70 ± 0.61

Pancreatic prohormone

2.39 ± 0.79

4.29 ± 0.91*

3.71 ± 1.22*

Protein S100-A11

2.73 ± 0.36

2.62 ± 0.36

2.56 ± 0.46

Amphiregulin

1.28 ± 0.46

1.26 ± 0.37

1.21 ± 0.41

Endothelial cell-specific molecule 1

7.99 ± 0.48

8.02 ± 0.47

8.09 ± 0.52

C-type lectin domain family 4 member K

2.29 ± 0.34

2.22 ± 0.30

2.24 ± 0.45

ICOS ligand

6.13 ± 0.38

6.00 ± 0.46

6.11 ± 0.39

WAP four-disulfide core domain protein 2

6.38 ± 0.32

6.36 ± 0.30

6.32 ± 0.40

C-X-C motif chemokine 13

8.26 ± 0.57

8.20 ± 0.51

8.32 ± 0.60

Mothers against decapentaplegic homolog 5

1.76 ± 0.46

1.80 ± 0.55

1.78 ± 0.56

A disintegrin and metalloproteinase with thrombospondin motifs 15

0.35 ± 0.43

0.45 ± 0.42

0.35 ± 0.52

CD70 antigen

2.84 ± 0.35

2.87 ± 0.38

2.90 ± 0.55

R-spondin-3

− 0.20 ± 0.36

− 0.28 ± 0.36

− 0.07 ± 0.53

Folate receptor gamma

6.51 ± 1.69

6.48 ± 1.75

6.44 ± 1.75

Carcinoembryonic antigen-related cell adhesion molecule 5

1.45 ± 0.62

1.38 ± 0.70

1.48 ± 0.64

Vascular endothelial growth factor receptor 3

5.56 ± 0.25

5.54 ± 0.25

5.51 ± 0.31

Mucin-16

3.07 ± 0.85

3.12 ± 0.78

3.14 ± 0.92

Wnt inhibitory factor 1

5.23 ± 0.47

5.12 ± 0.42

5.16 ± 0.50

Granzyme B

1.91 ± 0.81

1.75 ± 0.86

1.85 ± 0.90

Fc receptor-like B

− 0.39 ± 0.55

− 0.33 ± 0.55

− 0.38 ± 0.57

Annexin A1

1.93 ± 0.43

1.82 ± 0.47

1.69 ± 0.50

Folate receptor alpha

5.83 ± 0.29

5.79 ± 0.28

5.81 ± 0.43

  1. All values are in arbitrary units (Mean ± SD)
  2. * Indicates significant difference (P < 0.001), compared to fasting values
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BMC Research Notes

ISSN: 1756-0500

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