Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice

Table 1 Fold regulation of endothelial cell biology genes in the liver of dengue virus infected mice as compared to mock infected mice

Gene symbol	Description	Fold regulation^a	p value^b
SERPINE1	Serine (or cysteine) peptidase inhibitor, clade E, member 1	27.9817	0.046792
CCL2	Chemokine (C–C motif) ligand 2	17.9509	0.010773
VCAM1	Vascular cell adhesion molecule 1	6.4031	0.039317
ICAM1	Intercellular adhesion molecule 1	4.9573	0.001673
MMP9	Matrix metallopeptidase 9	4.2087	0.017157
SELPLG	Selectin, platelet (p-selectin) ligand	4.0692	0.012107
SELL	Selectin, lymphocyte	2.9629	0.008503
PF4	Platelet factor 4	2.8456	0.002018
PROCR	Protein C receptor, endothelial	2.6883	0.010671
ITGB3	Integrin beta 3	2.3885	0.004266
BCL2L1	Bcl2-like 1	2.3017	0.005111
TGFB1	Transforming growth factor, beta 1	1.9354	0.018087
SELP	Selectin, platelet	1.7322	0.00361
KIT	Kit oncogene	1.51	0.019643
FN1	Fibronectin 1	1.4884	0.038106
CASP3	Caspase 3	− 1.5606	0.000338
TYMP	Thymidine phosphorylase	− 2.1416	0.015268

AG129 mice were intraperitoneally inoculated with 2 × 10⁶ PFU dengue virus, New Guinea C strain. Mock infected AG129 mice were intraperitoneally inoculated with media only
^aFold regulation of > 1.5 and > − 1.5 were considered upregulation and downregulation, respectively as compared to the gene expression level in the mock infected mice
^bThe differences in gene expression level was considered significance at a p value of < 0.05

ISSN: 1756-0500