Fig. 1
Effects of TAE226 on signaling pathways and tumor growth in MIA PaCa-2 models. a Effects of TAE226 on phosphorylation of FAK at Y397, Akt at S473 and ERK1/2 in MIA PaCa-2 cells treated for 1 h. b Effects of TAE226 on phosphorylation of FAK at Y397, Akt at S473 and ERK1/2 in MIA PaCa-2 tumors. Tumor samples were collected 3 h after administration of TAE226 at doses of 10, 30 and 100 mg/kg. Two or three animals were used for each group and each lane represents an individual animal. c Effects of TAE226 on MIA PaCa-2 subcutaneous tumor growth (n = 7). Tumor volume was calculated according to the formula: length × width2/2. d Effects of TAE226 on MIA PaCa-2 orthotopic tumor growth (n = 8). Values are expressed by mean ± SEM. Gemcitabine was administered intravenously twice weekly