Fig. 1

Effect of 5-HOB on neuropathic allodynia (CCI operated). Effect of 5-HOB on the operated hind paw withdrawal threshold to pressure of von Frey hairs in time course (a) and on day 42 (b). The dotted lines in A indicate the surgery performed on day 0 and the treatment start on day 14 with vehicle or 5-HOB. Values are expressed as means ± SEM (n = 7 ~ 8). a Tukey’s multiple comparison test following 2 way ANOVA; ^*P < 0.05, ^**P < 0.01 versus CCI Vehicle. b Sidak’s multiple comparison test following 1 way ANOVA; ^**P < 0.01, ns: no significant difference versus Sham Vehicle, ^##P < 0.01, NS: no significant difference versus CCI Vehicle