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Table 3 Association between HIV clinical data and HIV infection type

From: Evaluation of hepatic and kidney dysfunction among newly diagnosed HIV patients with viral hepatitis infection in Cape Coast, Ghana

Clinical data Description HIV1 mono-infection
(n = 68)
HIV1/HBV co-infection
(n = 22)
p-value
   Median (IQR)  
Hb (g/dL)   10. 0 (8.5–11.8) 10.4 (8.8–11.4) 0.917
PLT (109/L)   208 (165.0–245.0) 230 (167.3–256.3) 0.460
ALT (U/L)   28.1(18.1–34.7) 25.6 (17.3–45.3) 0.821
AST (U/L)   30.6 (23.8–45.0) 33.0 (27.5–58.9) 0.123
Creatinine (mg/dL)   80.0 (65.1–106.2) 89.8 (62.0–118.2) 0.351
  ALT (U/L) Hepatotoxicity, n (%)  
Absent < 50.0 64 (91.4) 19 (86.4) 0.355
Present ≥ 50.0 4 (5.9) 3 (13.6)
Grade 1 50.0–99.9 4 (5.9) 1 (4.5) 0.042
Grade 2 100.0–199.9 0 (0.0) 2 (9.1)
Grade 3 and 4 ≥ 200.0 0 (0.0) 0 (0.0)
  APRI Liver fibrosis, n (%)  
Absent < 1.5 67 (98.5) 21 (95.5) 0.431
Present > 1.5 1 (1.5) 1 (4.5)
  eGFR (mL/min/1.73 m2) CKD, n (%)  
Absent ≥ 60 58 (85.3) 18 (81.8) 0.696
Present < 60 10 (14.7) 4 (18.2)
Stage 1 ≥ 90
Normal GFR
40 (58.8) 10 (45.5) 0.053
Stage 2 60–89
Mildly reduced GFR
18(26.5) 8 (36.4)
Stage 3 30–59
Moderately reduced GFR
10 (14.7) 2 (9.1)
Stage 4 15–29
Severely reduced GFR
0 (0.0) 2 (9.1)
   n (%)  
HIV stages Stage 1 47 (52.2) 17 (18.9) 0.86
Stage 2 10 (11.1) 3 (3.3)
Stage 3 6 (6.7) 1 (1.1)
Stage 4 5 (5.6) 1 (1.1)
  1. Mann–Whitney test was used to compare levels of Hb, PLT, ALT and AST. Where IQR = interquartile range. Association analyses of infection type with hepatotoxicity, liver fibrosis CKD or HIV stages were done using Pearson’s Chi-square test or Fisher’s exact test. A two-tailed p-value was considered significant at p < 0.05