Evaluation of hepatic and kidney dysfunction among newly diagnosed HIV patients with viral hepatitis infection in Cape Coast, Ghana

Table 3 Association between HIV clinical data and HIV infection type

Clinical data	Description	HIV1 mono-infection (n = 68)	HIV1/HBV co-infection (n = 22)	p-value
		Median (IQR)
Hb (g/dL)		10. 0 (8.5–11.8)	10.4 (8.8–11.4)	0.917
PLT (10⁹/L)		208 (165.0–245.0)	230 (167.3–256.3)	0.460
ALT (U/L)		28.1(18.1–34.7)	25.6 (17.3–45.3)	0.821
AST (U/L)		30.6 (23.8–45.0)	33.0 (27.5–58.9)	0.123
Creatinine (mg/dL)		80.0 (65.1–106.2)	89.8 (62.0–118.2)	0.351
	ALT (U/L)	Hepatotoxicity, n (%)
Absent	< 50.0	64 (91.4)	19 (86.4)	0.355
Present	≥ 50.0	4 (5.9)	3 (13.6)	0.355
Grade 1	50.0–99.9	4 (5.9)	1 (4.5)	0.042
Grade 2	100.0–199.9	0 (0.0)	2 (9.1)
Grade 3 and 4	≥ 200.0	0 (0.0)	0 (0.0)
	APRI	Liver fibrosis, n (%)
Absent	< 1.5	67 (98.5)	21 (95.5)	0.431
Present	> 1.5	1 (1.5)	1 (4.5)	0.431
	eGFR (mL/min/1.73 m²)	CKD, n (%)
Absent	≥ 60	58 (85.3)	18 (81.8)	0.696
Present	< 60	10 (14.7)	4 (18.2)	0.696
Stage 1	≥ 90 Normal GFR	40 (58.8)	10 (45.5)	0.053
Stage 2	60–89 Mildly reduced GFR	18(26.5)	8 (36.4)
Stage 3	30–59 Moderately reduced GFR	10 (14.7)	2 (9.1)
Stage 4	15–29 Severely reduced GFR	0 (0.0)	2 (9.1)
		n (%)
HIV stages	Stage 1	47 (52.2)	17 (18.9)	0.86
	Stage 2	10 (11.1)	3 (3.3)
	Stage 3	6 (6.7)	1 (1.1)
	Stage 4	5 (5.6)	1 (1.1)

Mann–Whitney test was used to compare levels of Hb, PLT, ALT and AST. Where IQR = interquartile range. Association analyses of infection type with hepatotoxicity, liver fibrosis CKD or HIV stages were done using Pearson’s Chi-square test or Fisher’s exact test. A two-tailed p-value was considered significant at p < 0.05

ISSN: 1756-0500