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Table 3 Summarizing the association of independent variable with ALT/AST level via logistic regression analysis in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital, Northeast Ethiopia

From: Liver enzyme elevation in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital: a comparative cross-sectional study, Northeast Ethiopia

Variables ALT/AST Level COR Sig AOR
Normal Elevated
Age
 ≤ 35 years 63 (41.4) 14 (9.2) 1 1 1
 > 35 years 63 (41.4) 12 (7.9) 1.167 (0.500–2.210) 0.721 1.152 (0.438–3.031)
Sex
 Male 52 (34.2) 9 (5.9) 1 1 1
 Female 74 (48.7) 17 (11.2) 0.753 (0.312–1.821) 0.529 1.255 (0.427–3.690)
Marital status
 Single 24 (15.8) 4 (2.6) 1 1 1
 Married 54 (35.5) 15 (9.9) 0.600 (0.180–1.998) 0.405 0.510 (0.137–1.908)
 Divorced 28 (18.4) 3 (2) 1.556 (0.316–7.652) 0.587 1.947 (0.311–12.184)
 Widowed 20 (13.2) 4 (2.6) 0.433 (0.140–1.338) 0.813 1.019 (0.178–5.826)
Residence
 Urban 98 (64.5) 23 (15.1) 1 1 1
 Rural 28 (18.4) 3 (2) 2.190 (0.613–7.834) 0.228 0.304 (0.072–1.280)
Educational status
 No formal education 23 (15.1) 9 (5.9) 0.249 (0.069–0.900) 0.034 0.130 (0.029–0.592)
 Primary education 62 (40.8) 13 (8.6) 0.465 (0.142–1.527) 0.207 0.338 (0.092–1.242)
 Secondary and above 41 (27) 4 (2.6) 1 1 1
Clinical stage
 Stage I 45 (29.6) 8 (5.3) 1 1 1
 Stage II 30 (19.7) 6 (3.9) 0.889 (0.280–2.821) 0.842 1.491 (0.364–6.108)
 Stage III 42 (27.6) 11 (7.2) 0.679(0.249–1.851) 0.449 0.607 (0.193–1.908)
 Stage IV 9 (5.9) 1 (0.7) 1.600 (0.178–14.42) 0.675 1.635 (0.151–17.723)
Body mass index
 < 18.5 22 (14.5) 9 (5.9) 1 1 1
 18.6–24.9 88 (57.9) 15 (9.9) 2.400 (0.929–6.201) 0.071a 3.387 (1.119–10.265)
 ≥ 25 16 (10.5) 2 (1.3) 3.273 (0.621–17.247) 0.162 3.333 (0.536–20.733)
CPT-prophylaxis
 Yes 61 (40.1) 18 (11.8) 0.417 (0.169–1.029) 0.058 0.280 (0.093–0.842)
 No 65 (42.8) 8 (5.3) 1 1 1
Regimens
 d4T-3TC-NVP 8 (10.5) 2 (2.6) 1.455 (0.212–9.984) 0.703 2.710 (0.100–73.157)
 d4T-3TC-EFV 2 (2.6) 2 (2.6) 0.364 (0.038–3.518) 0.382 0.308 (0.003–33.145)
 ZDV-3TC-NVP 16 (21.1) 3 (3.9) 1.939 (0.361–10.430) 0.440 5.898 (0.287–121.288)
 ZDV-3TC-EFV 11 (14.5) 3 (3.9) 1.212 (0.216–6.800) 0.827 2.403 (0.133–43.467)
 TDF-3TC-NVP 9 (11.8) 5 (6.6) 0.655 (0.134–3.186) 0.600 0.519 (0.028-9.727)
 TDF-3TC-EFV 11 (14.5) 4 (5.3) 1 1 1
  1. COR crude odd ratio, AOR adjusted odds ratio, d4T stavudine, 3TC lamivudine, NVP nevirapine, EFV efavirenz, ZDV zidovudine, TDF tenofovir
  2. aMultiple logistic regression statically significant, ALT normal value for male ULN ≤ 40 U/L, for female ALT ≤ 35 U/L and AST value for male ≤ 35 U/L and AST value for female ≤ 31 U/L