Fig. 3

Cochlear histology. a–d Representative images of organs of Corti in the 32-kHz region [a wild-type (WT) mice at 2 months, b Fat-1 mice at 2 months, c WT mice at 16–17 months, and d Fat-1 mice at 16–17 months]. At 32 kHz, almost all OHCs were intact in the early stage (a, b), but were severely damaged at 16–17 months in both WT and Fat-1 mice (c, d). e Quantitative data for OHC survival at 2 months. f Quantitative data of OHC survival at 16–17 months. g–j Representative images of the cochlear middle turn (g wild-type [WT] mice at 2 months, h Fat-1 mice at 2 months, i WT mice at 16–17 months, and j Fat-1 mice at 16–17 months). There were no apparent differences between these two groups at either 2 or 13 months. k Quantitative data for spiral ganglion (SG) neuron counts at 13 months. l Quantitative data for stria vascularis (SV) thickness measurements at 13 months. P values < 0.05 were considered statistically significant (*). ns no significant difference