Table 1 The frequency (%) of CTLA-4 +49 A/G polymorphism

AA

5 (20.8)

140 (58.3)

162 (67.5)

All < 0.001

LADA vs. T1DM = 0.001

0.18

0.06–0.52

LADA vs. controls = 0.001

0.12

0.04–0.35

T1DM vs. controls = 0.037

0.67

0.46–0.97

AG

16 (66.7)

85 (35.4)

70 (29.2)

All < 0.001

LADA vs. T1DM = 0.002

3.64

1.49–8.87

LADA vs. controls = 0.001

4.85

1.98–11.86

T1DM vs. controls = 0.143

1.33

0.90–1.95

GG

3 (12.5)

15 (6.3)

8 (3.3)

All 0.087

LADA vs. T1DM = 0.598

0.74

0.20–2.50

LADA vs. controls = 0.598

0.74

0.20–2.50

T1DM vs. controls = 0.990

1.00

0.61–1.61

AG + GG

19 (79.1)

100 (41.7)

78 (32.5)

All < 0.001

LADA vs. T1DM = 0.018

3.21

1.16–8.89

LADA vs. controls = 0.001

4.49

1.62–12.42

T1DM vs. controls = 0.067

1.73

0.97–2.00

Allele A

26 (54.2)

365 (76.0)

394 (82.1)

All < 0.001

Allele G

22 (45.8)

115 (24.0)

86 (18.0)

LADA vs. T1DM < 0.001

0.37

0.20–0.68

LADA vs. controls < 0.001

0.25

0.13–0.47

T1DM vs. controls = 0.021

0.69

0.50–0.94