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Table 1 Baseline demographic and clinical characteristics of study participants by childhood trauma exposure

From: The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

 All participants (n = 73)Childhood trauma (n = 54)No childhood trauma (n = 19)tUχ2P
Mean age in years ± SD35.23 ± 7.2435.81 ± 6.6033.58 ± 8.80)–1.16  0.250
Median years of education (interquartile range)11.00 (9.00 –11.00)10.00 (9.00 –11.00)11.00 (10.00–12.00) 362.00 0.052
Median viral load (interquartile range)a18,459.50 (1732.25–64,831.75)24,510.00 (4478.00–64,634.50)9759.00 (1284.50–50,905.50) 320.50 0.023
Median log-transformed viral load (interquartile range)a4.26 (3.20 –4.82)4.39 (3.52 –4.81)3.99 (3.08–4.87) 140.00 0.332
Median CD4 count (interquartile range)453.00 (270.50–664.25)432.00 (259.50–643.75)481.50 (410.25–677.75) 412.00 0.336
Median CD8 count (range)834.00 (620.50–1107.75)768.00 (539.00–1090.00)1050.00 (754.00–1284.00) 357.50 0.203
On ART treatment56479  12.380.001
AA37 b     1.110.574
I330    
AA41b     2.780.427
S24204    
N1275    
AA55b     5.610.061
A13130    
Hetero- or homozygous for the ApoE ε4 allelec26188  1.720.190
Mean baseline global cognitive score ± SD–0.02 ± 0.55–0.08 ± 0.540.15 ± 0.531.61  0.112
Mean follow-up global cognitive score ± SD–0.12 ± 0.53–0.19 ± 0.550.07 ± 0.411.88  0.064
  1. AA amino acid, ApoE apoliprotein E, ART antiretroviral therapy, SD standard deviation
  2. Parametric and non-parametric data are represented as mean ± SD and median and interquartile range respectively
  3. aViral load comparisons included the 38 participants with a viral load of greater than or equal to 40, the lower limit of sensitivity of the assay
  4. bAmino acid data was available for 66 participants
  5. cApoE ε4 allele comparison included the 63 participants for whom genotype information was available