Table 2 Factors associated with the development of hepatotoxicity (Bivariate analysis)
From: Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia
No | Variable | P value | OR | 95% CI |
|---|---|---|---|---|
1 | BMI (18.6–24.9 kg m2) | – | 1 | Reference |
BMI (< 18.5 kg m2) | 0.003 | 6.648 | (1.941–22.771) | |
2 | Alcohol history (no) | – | 1 | Reference |
Yes | 0.028 | 4.023 | (1.165–13.885 | |
3 | Type of TB (PTB) | 0.011 | 1 | Reference |
Extra pulmonary | 0.019 | 4.487 | (1.286–15.655) | |
Disseminated | 0.011 | 8.333 | (1.642–42.283) | |
4 | WHO clinical staging (3) | – | 1 | Reference |
Stage 4 | 0.002 | 5.844 | (1.865–18.314) | |
5 | OI- prophylaxis (no) | 0.064 | 1 | Reference |
CPT | 0.401 | 2.537 | (0.289–22.226) | |
CPT and INH | 0.066 | 8.0 | (0.872–73.397) | |
6 | Adherence (good) | 0.027 | 1 | Reference |
Fair | 0.058 | 3.545 | (0.958–13.128) | |
Poor | 0.009 | 8.125 | (1.689–39.085) | |
7 | Viral load (undetected) | – | 1 | Reference |
Detected | 0.020 | 3.750 | (1.226–11.468) |