Table 1 The estimated colony forming unit and median lethal concentration (LD50) of pathogenic microorganisms’ antigens and vaccines
Pathogenic microbes | Animal model | Antigen(s)/Strain | Route | CFU (LC1) | LC50 cfu/ml | Comments | Reference(s) |
|---|---|---|---|---|---|---|---|
Staphylococcus aureus | Mice | pC1-Neo pC1-Neo-MeccA | Intraperitoneal | 2.2 × 107 | 1.1 × 108 | Less virulent | [5] |
Staphylococcus aureus | Mice | Fibrinogen Fibronectin | Intravenous | 2 × 106 | 1 × 107* | Less virulent | [6] |
Staphylococcus aureus | Mice | Endotoxin-free PBS | Intraperitoneal | 1 × 108 | 5 × 108* | Less virulent | [10] |
New Castle disease virus | Chicken | Lasota vaccine | Oral | 0.84–1.92 | 4.2–9.6/ml | Very virulent | [11] |
New Castle disease virus | Chicken | 12 vaccine | Oral | 1.14–1.92 | 5.7–9.6/ml | Very virulent | [11] |
Hepatitis A Virus | In vitro | HAV AM75/18F | In vitro | 2.8 × 106 | 1.4 × 107 | Less virulent | [12] |
Streptococcus pneumoniae | Mice | Pneumococcal surface protein A | Subcut | 9 × 104–106 | 4.5 × 104–106 | Moderately virulent | [13] |
Streptococcus pneumoniae | Mice | PSPA1 and 2 bound to Vi polysaccharide | Intravenous | 2 × 103–2 × 106 | 104–107 | Moderately virulent | [14] |
Foot and Mouth Disease virus | In vitro cell line (hamster kidney 21 cell line) | Serotype A, 0 and SAT-2 | Cell culture | 2.8 × 108 | 1.4 × 109 | Less virulent | [15] |
Staphylococcus aureus | Rat | Strain (ATCC29213) | Intraperitoneal | 3.5 × 109 | 1.75 × 1010 | Less virulent | [16] |
Pseudomonas aeruginosa | Rat | (ATCC27853) strain | Intraperitoneal | 6 × 107 | 3.0 × 108 | Less virulent | [16] |
Sheep pox virus | Sheep | SPPV strain (Hd 2012) | Intradermal | 3.86 × 102 | 1.93 × 103 | Highly virulent | [17] |
Edwardsiella ictaluri | Catfish | Suspension of E. ictaluri | Intraperitoneal | 5.6 × 103 | 2.8 × 104 | Moderately virulent | [18] |
Aeromonas hydrophila | New Zealand rabbit, fish | Glycoprotein based-vaccine | Intradermal | 1 × 109 | 5 × 109 | Less virulent | [19] |
Aeromonas veronii | Fish mice | Bacteriovorax strain H2 | Oral | 7.2 × 108 | > 109 PFUg−1 | Less virulent | [20] |