Table 1 Therapeutic indices and safety margins of some chemicals and plant extract
Toxicant | Experimental | Weight of animal(kg) | LD50 (mg/kg) | ED50 (mg/kg) | LT50 | LD1 (mg/kg) | ED99 (mg/kg) | T1 (Control) | T2 | MS1 (Control) | MS2 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Animal | Antidote | |||||||||||
Amphetamine | Dog | d-Tubocucarine | 10 | 5.9 i.v | 2.0 | 2.9Â s | 0.118 | 3.96 | 2.95 | 3.0 | 0.03 | 0.13 |
Dextroamphetamine | Dog | d-Tubocucarine | 10 | 11.8 i.v | 3.9 | 7.3Â s | 0.236 | 7.72 | 3.02 | 3.0 | 0.03 | 0.11 |
Methamphetamine | Dog | d-Tubocucarine | 10 | 11.8 i.v | 3.9 | 7.3Â s | 0.236 | 7.72 | 3.02 | 3.0 | 0.03 | 0.11 |
Lysergic acid diethylamide | Rabbit | d-Tubocucarine | 1.8 | 0.3 i.v | 0.02 | 0.6Â s | 0.006 | 0.04 | 15.0 | 0.54 | 0.15 | 13.2 |
Potassium permanganate | Mouse | d-Tubocucarine | 0.02 | 1499.7 oral | 1.0 | 1.3Â h | 30.0 | 1.98 | 1499.7 | 0.003 | 15.1 | 1.58 |
Abrus precatorius | Human | d-Tubocucarine | 60 | 197 i.m | 394 | 5.2Â min | 3.94 | 780.1 | 0.5 | 18.0 | 0.005 | 0.002 |
Tetrahydroxy cannabinol | Rat | d-Tubocucarine | 0.15 | 29 i.v | 0.15 | 24.2Â min | 0.58 | 0.30 | 193.3 | 0.05 | 1.9 | 12.2 |