Table 2 Comparison of means or medians between CA-125, FASN, GLS, CA-125 + FASN, CA-125 + GLS, and CA-125 + FASN + GLS serums levels for the suboptimal and optimal cytoreduction groups and cut off point, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for each variable
From: The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
Variable | Group | P value | Cut off point | Sensitivity | Spesificity | Accuracy rate | Positive predictive value | Negative predictive value | P value | |
|---|---|---|---|---|---|---|---|---|---|---|
Suboptimal cytoreduction | Optimal cytoreduction | |||||||||
N = 56 | N = 53 | |||||||||
CA-125 | 0.0001 | 248.55 | 73.2% | 73.6% | 73.3% | 74.5% | 72.2% | 0.0001 | ||
Mean ± Std | 1157.62 ± 2105.195 | 237.52 ± 319.431 | ||||||||
Median | 600.00 | 120.30 | ||||||||
Range (min–max) | 4.29–9934.00 | 5.10–1941.90 | ||||||||
FASN | 0.006 | 0.445 | 62.5% | 60.4% | 61.4% | 62.5% | 60.4% | 0.017 | ||
Mean ± Std | 0.58 ± 0.271 | 0.46 ± 0.288 | ||||||||
Median | 0.50 | 0.37 | ||||||||
Range (min–max) | 0.11–1.59 | 0.03–1.19 | ||||||||
GLS | 0.0001 | 22.895 | 73.2% | 75.5% | 74.3% | 75.9% | 72.7% | 0.0001 | ||
Mean ± Std | 25.19 ± 5.415 | 20.83 ± 5.562 | ||||||||
Median | 25.25 | 20.08 | ||||||||
Range (min–max) | 14.27–37.50 | 10.81–38.01 | ||||||||
Combination CA-125 + FASN | 0.0001 | 0.69 | 71.4% | 71.7% | 71.6% | 72.7% | 70.4% | 0.0001 | ||
Mean ± Std | 1.02 ± 0.581 | 0.55 ± 0.314 | ||||||||
Median | 0.93 | 0.49 | ||||||||
Range (min–max) | 0.21–3.18 | 0.03–1.58 | ||||||||
Combinantion CA-125 + GLS | 0.0001 | 29.16 | 82.1% | 73.6% | 77.9% | 76.6% | 79.6% | 0.0001 | ||
Mean ± Std | 42.93 ± 12.913 | 25.83 ± 9.807 | ||||||||
Median | 44.99 | 22.47 | ||||||||
Range (min–max) | 17.15–75.00 | 10.81–53.52 | ||||||||
Combination CA-125 + FASN + GLS | 0.0001 | 0.83 | 87.5% | 73.6% | 80.7% | 77.8% | 84.8% | 0.0001 | ||
Mean ± Std | 1.70 ± 0.967 | 0.66 ± 0.388 | ||||||||
Median | 1.48 | 0.66 | ||||||||
Range (min–max) | 0.22–4.68 | 0.03–2.16 | ||||||||