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Table 2 Comparison of means or medians between CA-125, FASN, GLS, CA-125 + FASN, CA-125 + GLS, and CA-125 + FASN + GLS serums levels for the suboptimal and optimal cytoreduction groups and cut off point, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for each variable

From: The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers

Variable Group P value Cut off point Sensitivity Spesificity Accuracy rate Positive predictive value Negative predictive value P value
Suboptimal cytoreduction Optimal cytoreduction
N = 56 N = 53
CA-125 0.0001 248.55 73.2% 73.6% 73.3% 74.5% 72.2% 0.0001
 Mean ± Std 1157.62 ± 2105.195 237.52 ± 319.431         
 Median 600.00 120.30         
 Range (min–max) 4.29–9934.00 5.10–1941.90         
FASN 0.006 0.445 62.5% 60.4% 61.4% 62.5% 60.4% 0.017
 Mean ± Std 0.58 ± 0.271 0.46 ± 0.288         
 Median 0.50 0.37         
 Range (min–max) 0.11–1.59 0.03–1.19         
GLS 0.0001 22.895 73.2% 75.5% 74.3% 75.9% 72.7% 0.0001
 Mean ± Std 25.19 ± 5.415 20.83 ± 5.562         
 Median 25.25 20.08         
 Range (min–max) 14.27–37.50 10.81–38.01         
Combination CA-125 + FASN 0.0001 0.69 71.4% 71.7% 71.6% 72.7% 70.4% 0.0001
 Mean ± Std 1.02 ± 0.581 0.55 ± 0.314         
 Median 0.93 0.49         
 Range (min–max) 0.21–3.18 0.03–1.58         
Combinantion CA-125 + GLS 0.0001 29.16 82.1% 73.6% 77.9% 76.6% 79.6% 0.0001
 Mean ± Std 42.93 ± 12.913 25.83 ± 9.807         
 Median 44.99 22.47         
 Range (min–max) 17.15–75.00 10.81–53.52         
Combination CA-125 + FASN + GLS 0.0001 0.83 87.5% 73.6% 80.7% 77.8% 84.8% 0.0001
 Mean ± Std 1.70 ± 0.967 0.66 ± 0.388         
 Median 1.48 0.66         
 Range (min–max) 0.22–4.68 0.03–2.16