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Table 2 Candidate genes for differential expression

From: Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

Gene Cytoband Fold-change P value Function
9q genes gain vs no gain
 HAPLN1 5q14.3 +5.2 0.000008 ECM protein and ERK signalling; overexpressed in metastatic melanoma and mesotheliomas
 PRAME 22q11.22 +3.6 0.000342 Repressor of retinoic acid receptor. Overexpressed in multiple neoplasms (including melanoma)
 SLC17A3 6p22.2 +3.3 0.000081 Voltage-driven transporter. Affects serum uric acid levels
 CKS2 9q22.2 +3.3 0.000232 CDC28 protein kinase regulatory subunit 2. Overexpressed in numerous neoplasms, overrides the intra-S-phase DNA damage checkpoint
 ANOS1 Xp22.31 +2.8 0.000297 ECM protein. Putative cell adhesion molecule, upregulated in some tumour types
 RNF182 6p23 +2.5 0.000110 E3 ubiquitin ligase. Overexpressed in Alzheimers
 SLC17A1 6p22.2 +2.3 0.000711 Sodium-dependent phosphate transporter. Affects uric acid levels
 CRB1 1q31.3 +2.1 0.000466 Photoreceptor protein
 SYT14 1q32.2 +2.1 0.000601 Family of proteins involved in synaptic transmission
 C6orf115 6q24.1 +2 0.000848 Uncharacterised protein
 APOD 3q29 −2.6 0.000762 Putative lipoprotein metabolism. Inverse correlation between expression and colorectal tumour progression. Associated with neurodegeneration
 CLU 8p21.1 −2.4 0.000751 Secreted anti-apoptotic chaperone protein. Overexpressed in many tumour types and associated with neurodegeneration
 SLFN11 17q12 −2.3 0.000237 Putative DNA/RNA helicase. Expression of other family members inhibits growth of fibroblasts and thymoctyes. Sensitises cancer cells to DNA damaging agents
chr12 genes gain vs no gain
 NDST3 4q26 +2.9 0.000814 N-deacetylase/N-sulfotransferase 3. Golgi apparatus protein, associated with schizophrenia and bipolar disorder
 PRELP 1q32.1 −2.2 0.000646 Connective tissue ECM protein. Abnormally expressed in chronic lymphocytic leukaemia cells
16q genes loss vs no loss
 PRAME 22q11.22 +6.4 0.000347 Repressor of retinoic acid receptor. Overexpressed in multiple neoplasms (including melanoma).
 GLRA2 Xp22.2 +2.7 0.000412 Glycine receptor alpha 2, neutrophil and p38 MAPK associated
 GABRA5 15q12 +2.5 0.000136 GABA receptor alpha 5, associated with schizophrenia and bipolar I disorder
 SLFN11 17q12 −3.6 0.000336 Putative DNA/RNA helicase. Expression of other family members inhibits growth of fibroblasts and thymoctyes. Sensitises cancer cells to DNA damaging agents