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Table 3 Clinical outcomes and adverse events

From: Clinical efficacy and bleeding outcomes of tissue plasminogen activator and dornase alfa in pleural space infection with once daily concurrent administration: a retrospective cohort study

Treatment outcomes

Data

Treatment success, n (%)

52 (92.9)

Surgical intervention for treatment failure (VATS with decortication), n (%)

2 (3.6)

30 day mortality due to pleural infection, n (%)

2 (3.6)

30 day readmission rate, n (%)

0 (0)

Median hospital stay (IQR)

15 (11–28)

Median cumulative volume of pleural drainage 24 h after first dose of intrapleural therapy (IQR), mL

447.5 (177.5–769.75)

Median cumulative volume of pleural drainage 48 h after first dose of intrapleural therapy (IQR), mL

995 (520–1445.5)

Median cumulative volume of pleural drainage 72 h after first dose of intrapleural therapy (IQR), mL

1470 (717.5–1989.75)

Median days of chest tube in pleural cavity (IQR)

10 (7–14)

Bleeding outcomes

Pleural bleeding

9 (16.1)

Pleural bleeding requiring ≥ 2U pRBC transfusion

5 (8.9)

Gastrointestinal bleeding

0 (0)

Intracranial bleeding

0 (0)

Other bleeding

0 (0)

Mean hemoglobin loss (SD), g/dL

3.5 (1.1)

Median units of pRBC transfusion in patients transfused (IQR)

2 (2–5)

Surgical intervention for pleural bleeding, n (%)

3 (5.4)

30 day mortality due to pleural bleeding, n (%)

0 (0)