Skip to main content

Table 1 Characteristics of IMD cases

From: Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease

   2018 2019 2020
01 Jan–15 March 16 March–15 May Total 01 Jan–15 March 16 March–15 May Total 01 Jan–15 March 16 March–15 May Total
IMD cases without respiratory presentations   118 71 P = 0.001* 189 103 66 P = 0.001 169 93 18 111
Sex ratio (M/F)   1 (59/59) 1.09 (37/34) 1.03 (96/93) 0.72 (43/60) 0.83 (30/36) 0.78 (73/96) 0.79 (41/52) 1 (9/9) 0.82 (50/61)
Median Age (Interquartile range Q1–Q3) y   21.3 (2.4–46.6) 20.6 (2.5–42.8) 20.7 (2.4–43.2) 25.1 (2.9–56.7) 18.7 (1.4–52.8) 21.1 (2.4–54.3) 21.4 (5.3–56.9) 15.9 (1.7–47.9) 20.5 (3.2–55.8)
Serogroup B 56 35 91 58 26 84 49 10 59
C 30 15 45 13 13 26 10 0 10
W 17 13 30 19 20 39 24 3 27
Y 15 7 22 10 6 16 9 4 13
Others 0 1 1 3 1 4 1 1 2
Clonal complexes Hyperinvasive clonal complexes 75 42 117 59 42 101 49 9 58
Non-hyperinvasive clonal complexes 29 21 50 39 21 60 39 9 48
IMD cases with respiratory presentations   11 2 13, P = 0.029 5 2 7, P = 0.002 13 5 18
Sex ratio (M/F)   0.22 (2/9) 0 (0/2) 0.18 (2/11) 0.25 (1/4) 0 (0/2) 0.17 (1/6) 0.86 (6/7) 0.25 (1/4) 0.64 (7/11)
Median Age (Interquartile range Q1–Q3) y   67.5 (60.1–82.5) 89.2 (85.3–93.1) 74 (62.9–84.3) 82.2 (50.4–84.8) 47.0 (0.7–93.4) 82.2 (33.5–85.7) 86.8 (66–93.0) 50.1 (15.7–83.1) 70.7 (52.9–93.0)
Serogroup B 0 0 0, P = 0.036 0 0 0 3 0 3
C 3 1 4, P = 0.003 0 0 0 0 1 1
W 1 1 2 1 1 2 7 0 7
Y 7 0 7 3 1 4 3 2 5
Others 0 0 0 1 0 1 0 2 2
Clonal complexes Hyperinvasive clonal complexes 2 2 4 0 0 0 4 1 5
Non-hyperinvasive clonal complexes 7 0 7 3 2 5 8 3 11
All IMD   129 73 (P = 0.002) 202 108 68 (P = 0.001) 176 106 23 129
Sex ratio (M/F)   0.89 (61/68) 1.03(37/36) 0.94 (98/104) 0.69 (44/64) 0.79 (30/38) 0.73 (74/102) 0.80 (47/59) 0.77 (10/13) 0.80 (57/72)
Median Age (Interquartile range Q1–Q3) y   22.2 (2.8–58.3) 20.8 (4.5–44.2) 21.5 (2.8–51.7) 30.4 (4.9–59.6) 18.7 (1.4–53.1) 22.3 (2.5–56.6) 27.7 (6.8–65.9) 19.8 (3.0–50.4) 25 (5.3–64.1)
Serogroup B 56 35 91 58 26 84 52 10 62
C 33 16 49 13 13 26 10 1 11
W 18 14 (P = 0.005) 32 20 21 (P = 0.001) 41 31 3 34
Y 22 7 29 13 7 20 12 6 18
Others 0 1 1 4 1 5 1 3 4
Clonal complexes Hyperinvasive clonal complexes 79 44 123 59 42 101 53 10 63
Non-hyperinvasive clonal complexes 36 21 57 42 23 65 47 12 59
  1. *Chi squared test. The test compared the data for the years 2018 or 2019 to the corresponding data in the year 2020. Only significant P values are shown