Fig. 3

Co-localization of ADAM9 with Integrin α6 and Integrin α2β1 in VS tumor samples. a–f Immunofluorescence double-staining of ADAM9 (red) and Integrin α6 (green). a, b Co-localization (yellow) was mainly found in tumor tissue and c near blood vessels (arrows). d One VS did not express any detectable Integrin α6. e, f Demonstrate enriched co-localization along the tumor capsule (arrows). g, h Immunofluorescence double-staining of ADAM9 (red) and Integrin α2β1 (green). g Integrin α2β1 VS with ADAM9 co-localization. h Integrin α2β1 negative VS. DAPI = blue. Representative images of n = 20. The split-channel images are provided in Additional file 1 Fig. S3