Table 2 Univariate analysis for association between polymorphisms with and without pelvic organ prolapse
From: Collagen type 1A1, type 3A1, and LOXL1/4 polymorphisms as risk factors of pelvic organ prolapse
Gene | SNP ID | Allele | POP n (%) | Control n (%) | OR | 95% CI | P value |
|---|---|---|---|---|---|---|---|
COL3A1 | rs1800255 | GG | 21 (40.4) | 7 (25.9) | 1.0 (ref) | ||
AG | 25 (48.1) | 15 (55.6) | 0.56 | 0.18–1.58 | 0.27 | ||
AA | 6 (11.5) | 5 (18.5) | 0.4 | 0.1–1.76 | 0.22 | ||
COL1A1 | rs1800012 | CC | 52 (100) | 28 (100) | – | ||
CA | 0 | 0 | – | ||||
AA | 0 | 0 | – | ||||
LOXL1 | rs2165241 | CC | 42 (80.8) | 19 (67.9) | 1.0 (ref) | ||
CT | 8 (15.4) | 8 (28.6) | 0.45 | 0.15–1.40 | 0.17 | ||
TT | 2 (3.9) | 1 (3.6) | 0.9 | 0.08–20.20 | 0.94 | ||
LOXL4 | rs2862296 | AA | 11 (21.2) | 14 (51.9) | 1.0 (ref) | ||
AG | 27 (51.9) | 9 (33.3) | 3.8 | 1.30–11.80 | 0.01 | ||
GG | 14 (26.9) | 4 (14.8) | 4.5 | 1.20–19.30 | 0.02 |