Fig. 2

Dose–response curves and synergy scores produced from the different matrix sizes. a Relative cell viability plotted as a function of ara-C concentration at differing hydroxyurea (HU) or gemcitabine (dF-dC) doses. Mean values from four independent experiments plotted, error bars indicate s.e.m. b Drug synergy plots for ara-C and the indicated RNR inhibitor, either HU or dF-dC, using the different synergy models. Each data point indicates an average synergy score from a single dose–response matrix experiment performed in duplicate. Zero, > 0 or < 0 corresponds to additive, synergy or antagonism, respectively, whilst > 5 indicates strong synergy. The horizontal line and the error bars indicate the median and interquartile range, respectively, from four independent experiments. Statistical testing was carried out using the non-parametric Kruskal–Wallis test: ns not significant; *, p < 0.05