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Table 2 Distribution of FCN3 genotypes (rs4494157 and rs10794501) in controls and patients with RF

From: The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study

  Control n (%) RF without RHD n (%) RF with RHD n (%) OR (95% CI) P
rs4494157
Genotype distribution
 CC 64 (80) 49 (61.25) 43 (53.75)   
 CA 10 (12.5) 20 (25) 23 (28.75) 2.61 (1.12–6.08)a
3.42 (1.48 -7.91) b
0.026a*
0.005b*
 AA 6 (7.5) 11 (13.75) 14 (17.5) 3.47 (1.24–9.74) b 0.026b*
 CA/AA 16 (20) 31 (38.75) 37 (46.25) 2.53 (1.24–5.14) a
3.44 (1.70–6.95) b
0.016 a *
0.0007 b *
Allele frequencies
 C 138 (86.25) 118 (73.75) 109 (68.12)   
 A 22 (13.75) 42 (26.25) 51 (31.88) 2.23 (1.26–3.95)a
2.93 (1.68–5.14) b
0.008a*
0.0002b*
rs10794501
Genotype distribution
 TT 58 (72.5) 51 (63.75) 54 (67.5)   n.s
 TA 17 (21.25) 21 (26.25) 16 (20)
 AA 5 (6.25) 8 (10) 10 (12.5)
 TA/AA 22 (27.5) 29 (36.25) 26 (32.5)
Allele frequencies
 T 133 (83.1) 123 (76.9) 124 (77.5)   n.s
  A 27 (16.9) 37 (23.1) 36 (22.5)
  1. OR, odds ratio; CI, confidence intervals; RF, rheumatic fever; RHD, rheumatic heart disease; aRF patients without RHD vs. control; bRF patients with RHD vs. control; *Statistically significant different at P < 0.05 using Fisher exact test, n.s., non-significance