Skip to main content

Table 2 Analysis of polar interactions between EGF/EGFR in the untethered form of EGFR. The polar interactions between EGFR wild type (3NJP) and its mutated forms R521K and V550M revealed no changes in H-bonds with mutant R521K besides 1 missing and 1 extra H-bond (highlited in bold) with the mutant V550M

From: Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients

EGF (ligand)-EGFR (wild type) EGFR with (mutant R521K) EGFR with (mutant V550M)
 Lys28-Glu90 Lys28-Glu90 Lys28-Glu90
 Ala25-Ser99 Ala25-Ser99 Ala25-Ser99
 Asp11-Ser356 Asp11-Ser356 Asp11-Ser356
 Glu51-Ser468 Glu 51-Ser468 Glu51-Ser468
 Trp50-Lys465 Trp50-Lys465 Trp50-Lys465
 Lys48-Gln411 Lys48-Gln411 Lys48-Gln411
 Asp46-His409
 Lys48-His409
Asp46-His409
Lys48-His409
Asp46-His409
 Arg41 Arg41-Asp355 Arg41 Arg41-Asp355 Arg41 Arg41-Asp355
 Gln43-Gln384
 Arg45-Gln384
Gln43-Gln384
Arg45-Gln384
Gln43-Gln384
Arg45-Gln384
His16-Gln384
 Tyr44-His346 Tyr44-His346 Tyr44-His346
 Cys 33 Asn32-Gly18 Cys33 Asn32-Gly18 Cys33 Asn32-Gly18
 Cys33 Cys31-Gln16 Cys33 Cys31-Gln16 Cys33 Cys31-Gln16
 Cys31Glu40-Thr15 Cys31Glu40-Thr15 Cys31Glu40-Thr15
 Gly39-Asn12 Gly39-Asn12 Gly39-Asn12
 Glu40-Ser11 Glu40-Ser11 Glu40-Ser11