Table 2 Analysis of polar interactions between EGF/EGFR in the untethered form of EGFR. The polar interactions between EGFR wild type (3NJP) and its mutated forms R521K and V550M revealed no changes in H-bonds with mutant R521K besides 1 missing and 1 extra H-bond (highlited in bold) with the mutant V550M
EGF (ligand)-EGFR (wild type) | EGFR with (mutant R521K) | EGFR with (mutant V550M) |
|---|---|---|
Lys28-Glu90 | Lys28-Glu90 | Lys28-Glu90 |
Ala25-Ser99 | Ala25-Ser99 | Ala25-Ser99 |
Asp11-Ser356 | Asp11-Ser356 | Asp11-Ser356 |
Glu51-Ser468 | Glu 51-Ser468 | Glu51-Ser468 |
Trp50-Lys465 | Trp50-Lys465 | Trp50-Lys465 |
Lys48-Gln411 | Lys48-Gln411 | Lys48-Gln411 |
Asp46-His409 Lys48-His409 | Asp46-His409 Lys48-His409 | Asp46-His409 – |
Arg41 Arg41-Asp355 | Arg41 Arg41-Asp355 | Arg41 Arg41-Asp355 |
Gln43-Gln384 Arg45-Gln384 | Gln43-Gln384 Arg45-Gln384 | Gln43-Gln384 Arg45-Gln384 His16-Gln384 |
Tyr44-His346 | Tyr44-His346 | Tyr44-His346 |
Cys 33 Asn32-Gly18 | Cys33 Asn32-Gly18 | Cys33 Asn32-Gly18 |
Cys33 Cys31-Gln16 | Cys33 Cys31-Gln16 | Cys33 Cys31-Gln16 |
Cys31Glu40-Thr15 | Cys31Glu40-Thr15 | Cys31Glu40-Thr15 |
Gly39-Asn12 | Gly39-Asn12 | Gly39-Asn12 |
Glu40-Ser11 | Glu40-Ser11 | Glu40-Ser11 |