Table 2 Distribution of GSTM1 and GSTT1 genes variants according to control state of essential hypertension, SBP and DBP
Parameters | Genes-variants | Systolic Blood Pressure (SBP) | Diastolic Blood Pressure (DBP) | Hypertension | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Controlled n = 126 (%) | Uncontrolled n = 74 (%) | p value | Controlled n = 152 (%) | Uncontrolled n = 48 (%) | p value | Controlled n = 115 (%) | Uncontrolled n = 85 (%) | p value | ||
Monotherapy n = 110 | #GSTM1-active | 55 (74.32) | 30 (83.33) | 66 (76.74) | 19 (82.14) | 51 (76.12) | 34 (79.07) | |||
GSTM1-null | 19 (25.68) | 6 (16.77) | 0.34 | 20 (23.26) | 5 (17.86) | 1.00 | 16 (23.88) | 9 (20.93) | 0.48 | |
# GSTT1-active | 28 (37.84) | 10 (27.78) | 31 (36.05) | 7 (35.71) | 27 (40.30) | 11 (25.58) | ||||
GSTT1-null | 46 (62.16) | 26 (72.22) | 0.39 | 55 (63.95) | 17 (64.29) | 0.63 | 40 (59.70) | 32 (74.42) | 0.15 | |
Bitherapy n = 55 | # GSTM1-active | 17 (60.71) | 17 (70.83) | 24 (61.54) | 10 (64.71) | 16 (57.14) | 18 (66.67) | |||
GSTM1-null | 11 (39.29) | 7 (29.17) | 0.56 | 15 (38.46) | 6 (35.29) | 1.00 | 12 (42.86) | 9 (33.33) | 0.58 | |
# GSTT1-active | 14 (50.00) | 9 (37.50) | 16 (41.03) | 7 (41.18) | 11 (39.29) | 12 (44.44) | ||||
GSTT1-null | 14 (50.00) | 15 (62.50) | 0.41 | 23 (58.97) | 9 (58.82) | 1.00 | 17 (60.71) | 15 (55.56) | 0.78 | |
Tritherapy n = 35 | # GSTM1-active | 13 (61.91) | 9 (64.28) | 19 (70.37) | 3 (45.45) | 12 (60.00) | 10 (66.67) | |||
GSTM1-null | 8 (38.09) | 5 (35.72) | 1.00 | 8 (29.63) | 5 (54.55) | 0.11 | 8 (40.00) | 5 (33.33) | 0.73 | |
# GSTT1-active | 7 (33.33) | 8 (57.14) | 10 (37.04) | 5 (54.55) | 7 (35.00) | 8 (53.33) | ||||
GSTT1-null | 14 (66.67) | 6 (42.86) | 0.18 | 17 (62.96) | 3 (45.45) | 0.24 | 13 (65.00) | 7 (46.67) | 0.32 | |
Total n = 200 | # GSTM1-active | 85 (67.46) | 56 (75.68) | 109 (71.71) | 32 (69.64) | 79 (68.70) | 62 (72.94) | |||
GSTM1-null | 41 (32.54) | 18 (24.42) | 0.26 | 43 (28.29) | 16 (30.36) | 0.58 | 36 (31.30) | 23 (27.06) | 0.53 | |
# GSTT1-active | 49 (38.89) | 27 (36.49) | 57 (37.50) | 19 (41.07) | 45 (39.13) | 31 (36.47) | ||||
GSTT1-null | 77 (61.11) | 47 (63.51) | 0.76 | 95 (62.50) | 29 (58.93) | 0.86 | 70 (60.87) | 54 (63.53) | 0.76 | |
#GSTM1(+)/GSTT1(+) | 25 (19.84) | 16 (21.62) | 34 (24.34) | 7 (14.58) | 24 (20.87) | 17 (20.00) | ||||
GSTM1(−)/GSTT1(+) | 24 (19.05) | 11 (14.87) | 0.63 | 23 (15.13) | 12 (25.00) | 0.11 | 21 (18.26) | 14 (16.47) | 1.00 | |
GSTM1(+)/GSTT1(−) | 60 (47.62) | 40 (54.05) | 1.00 | 75 (49.34) | 25 (52.08) | 0.37 | 55 (47.83) | 45 (52.94) | 0.71 | |
GSTM1(−)/GSTT1(−) | 17 (13.49) | 7 (9.46) | 0.59 | 20 (13.16) | 4 (8.33) | 1.00 | 15 (13.04) | 9 (10.59) | 0.79 | |