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Table 2 Distribution of GSTM1 and GSTT1 genes variants according to control state of essential hypertension, SBP and DBP

From: Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso

Parameters Genes-variants Systolic Blood Pressure (SBP) Diastolic Blood Pressure (DBP) Hypertension
Controlled n = 126 (%) Uncontrolled n = 74 (%) p value Controlled n = 152 (%) Uncontrolled n = 48 (%) p value Controlled n = 115 (%) Uncontrolled n = 85 (%) p value
Monotherapy n = 110 #GSTM1-active 55 (74.32) 30 (83.33)   66 (76.74) 19 (82.14)   51 (76.12) 34 (79.07)  
GSTM1-null 19 (25.68) 6 (16.77) 0.34 20 (23.26) 5 (17.86) 1.00 16 (23.88) 9 (20.93) 0.48
# GSTT1-active 28 (37.84) 10 (27.78)   31 (36.05) 7 (35.71)   27 (40.30) 11 (25.58)  
GSTT1-null 46 (62.16) 26 (72.22) 0.39 55 (63.95) 17 (64.29) 0.63 40 (59.70) 32 (74.42) 0.15
Bitherapy n = 55 # GSTM1-active 17 (60.71) 17 (70.83)   24 (61.54) 10 (64.71)   16 (57.14) 18 (66.67)  
GSTM1-null 11 (39.29) 7 (29.17) 0.56 15 (38.46) 6 (35.29) 1.00 12 (42.86) 9 (33.33) 0.58
# GSTT1-active 14 (50.00) 9 (37.50)   16 (41.03) 7 (41.18)   11 (39.29) 12 (44.44)  
GSTT1-null 14 (50.00) 15 (62.50) 0.41 23 (58.97) 9 (58.82) 1.00 17 (60.71) 15 (55.56) 0.78
Tritherapy n = 35 # GSTM1-active 13 (61.91) 9 (64.28)   19 (70.37) 3 (45.45)   12 (60.00) 10 (66.67)  
GSTM1-null 8 (38.09) 5 (35.72) 1.00 8 (29.63) 5 (54.55) 0.11 8 (40.00) 5 (33.33) 0.73
# GSTT1-active 7 (33.33) 8 (57.14)   10 (37.04) 5 (54.55)   7 (35.00) 8 (53.33)  
GSTT1-null 14 (66.67) 6 (42.86) 0.18 17 (62.96) 3 (45.45) 0.24 13 (65.00) 7 (46.67) 0.32
Total n = 200 # GSTM1-active 85 (67.46) 56 (75.68)   109 (71.71) 32 (69.64)   79 (68.70) 62 (72.94)  
GSTM1-null 41 (32.54) 18 (24.42) 0.26 43 (28.29) 16 (30.36) 0.58 36 (31.30) 23 (27.06) 0.53
# GSTT1-active 49 (38.89) 27 (36.49)   57 (37.50) 19 (41.07)   45 (39.13) 31 (36.47)  
GSTT1-null 77 (61.11) 47 (63.51) 0.76 95 (62.50) 29 (58.93) 0.86 70 (60.87) 54 (63.53) 0.76
#GSTM1(+)/GSTT1(+) 25 (19.84) 16 (21.62)   34 (24.34) 7 (14.58)   24 (20.87) 17 (20.00)  
GSTM1(−)/GSTT1(+) 24 (19.05) 11 (14.87) 0.63 23 (15.13) 12 (25.00) 0.11 21 (18.26) 14 (16.47) 1.00
  GSTM1(+)/GSTT1() 60 (47.62) 40 (54.05) 1.00 75 (49.34) 25 (52.08) 0.37 55 (47.83) 45 (52.94) 0.71
GSTM1(−)/GSTT1(−) 17 (13.49) 7 (9.46) 0.59 20 (13.16) 4 (8.33) 1.00 15 (13.04) 9 (10.59) 0.79
  1. Values are expressed in numbers (percentages) and the comparison between groups was made using the chi-square test; *: significant difference between the groups (p < 0.05); #: reference; ( +): active; (−): null