Table 1 Functions of ectoine-coding genes in the Genus Halomonas under different scenarios
Gene symbol | Gene description/accepted name | EC number | KEGG Id (KO) & name | Gene name in patric server | Comment/involved in pathways & KEGG KO Id |
|---|---|---|---|---|---|
DoeA | Ectoine hydrolase DoeA | 3.5.4.44 | – | Ectoine hydrolase | The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108 |
DoeC | Aspartate-semialdehyde dehydrogenase | 1.2.1.11 | – | Aspartate-semialdehyde dehydrogenase DoeC in ectoine degradation | Threonine and Homoserine Biosynthesis Lysine Biosynthesis DAP Pathway, GJO scratch Lysine Biosynthesis DAP Pathway |
DoeX | DNA-binding protein DoeX, ectoine utilization regulator | No EC recorded | K15782 & Lrp/AsnC family transcriptional regulator, regulator of ectoine-degradation genes | DNA-binding protein DoeX, ectoine utilization regulator | Glycine, serine and threonine metabolism Monobactam biosynthesis Cysteine and methionine metabolism Lysine biosynthesis Metabolic pathways Biosynthesis of secondary metabolites Microbial metabolism in diverse environments |
EctC | Ectoine synthase | 4.2.1.108 | – | l-Ectoine synthase (EC 4.2.1.108) | Ectoine is an osmoprotectant that is found in halophilic eubacteria This enzyme is part of the ectoine biosynthesis pathway and only acts in the direction of ectoine formation |
EctD | Ectoine hydroxylase | 1.14.11.55 | – | Ectoine hydroxylase | The enzyme, found in bacteria, is specific for ectoine Glycine, serine and threonine metabolism Metabolic pathways |
EutB | Ethanolamine ammonia-lyase large subunit | 4.3.1.7 | – | Ectoine utilization protein EutB, threonine dehydratase-like | Glycerophospholipid metabolism Metabolic pathways |
EutC | Ethanolamine ammonia-lyase small subunit | 4.3.1.7 | – | Ectoine utilization protein EutC, similar to ornithine cyclodeaminase | Glycerophospholipid metabolism Metabolic pathways |
TeaA | TRAP transporter substrate-binding protein | No EC recorded | K11688 & C4-dicarboxylate-binding protein (DctP) | Ectoine/hydroxyectoine TRAP transporter substrate-binding periplasmic protein TeaA | – |
TeaB | Ectoine/hydroxyectoine TRAP transporter small permease protein | No EC recorded | – | Ectoine/hydroxyectoine TRAP transporter small permease protein TeaB | – |
TeaC | Ectoine/hydroxyectoine TRAP transporter large permease protein | No EC recorded | K11690 C4-dicarboxylate transporter, DctM subunit | Ectoine/hydroxyectoine TRAP transporter large permease protein TeaC | – |
UspA | Universal stress protein A | No EC recorded |  | Universal stress protein UspA in Ectoine TRAP cluster | – |