Fig. 2

Signaling molecules expression. A, D, G Representative image of western blots for phosphorylated and total SRC family kinases, p44/42 MAPK and CAMKII. B, E, H Relative ratio of phosphorylated proteins to total proteins. Each dot represents an individual rat (n = 4 for CT, KX and SD groups). C The mean difference between designated groups in the degree of phosphorylation of SRC was plotted as a bootstrap sampling distribution and is depicted as a black dot. Vertical error bar represents 95CI. The unpaired mean difference between the CT and KX groups was − 0.445 [95CI − 0.56, − 0.282] and between the CT and SD groups was 0.345 [95CI 0.115, 0.562]. F The mean difference between designated groups in the degree of phosphorylation of p44/42 MAPK was plotted as a bootstrap sampling distribution and is depicted as a black dot. Vertical error bar represents 95CI. The unpaired mean difference between the CT and KX groups was − 0.86 [95CI − 1.18, − 0.325] and between the CT and SD groups was 0.065 [95CI − 0.173, 0.263]. G The mean difference between designated groups in the degree of phosphorylation of CAMKII was plotted as a bootstrap sampling distribution and is depicted as a black dot. Vertical error bar represents 95CI. The unpaired mean difference between the CT and KX groups was 0.108 [95CI − 0.143, 0.305] and between the CT and SD groups was − 0.0075 [95CI − 0.165, 0.155]