Fig. 3

H1 refers to simulations under the alternative hypothesis of allelic imbalance within a condition and H3 refers to unequal levels of AI between the two conditions. For H1, the x-axis is the effect size, which is the relative deviation from allelic balance \({\Delta AI}_{1}=\) \(\frac{\left|\theta -{\theta }_{0}\right|}{{\theta }_{0}}\), where \({\theta }_{0}=0.5\). For H3, the x-axis is the relative difference in levels of AI between the two conditions \({\Delta AI}_{3}=\) \(\frac{\left|{\theta }_{2}-{\theta }_{1}\right|}{{\theta }_{1}}\) where the first condition is simulated under the null hypothesis and the second under the alternative hypothesis \(\theta \ne 0.5\). The power (y-axis) is computed as the proportion of simulations for which the Bayesian evidence against allelic balance within a condition or against equal levels of AI between conditions is \(<\) 0.05. There are 1000 simulations and the probability of an allele specific read is r_i,g1 = r_i,g2 = 0.8. Simulations for 3, 4, 5, 6, 8, and 12 biological replicates (bioreps, x-axis) for varying numbers (#) of allele specific reads are reported