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Table 1 General characteristics and biochemical characteristics of study participants across the CARTPT rs2239670 genotypes

From: Hypothalamic-pituitary hormones will be affected by the interaction between 5q13-14-rs2239670 (CARTPT) gene variants and diet in different obesity phenotypes

  Women Men
AA AG GG P* AA AG GG P*
Age (y) 35.85 (7.89) 37.44 (9.06) 38.41 (7.99) 0.56 40.40 (5.36) 42.27 ( 7.24) 37.24 (6.42) 0.01
BMI (kg/m2) 34.75 (4.22) 34.89 (3.63) 36.03 (4.46) 0.45 33.14 (2.38) 35.09 (5.52) 33.63 (2.53) 0.23
FM 38.24 (7.56) 36.07 (6.00) 39.53 (9.10) 0.30 24.80 (1.60) 32.18 (10.44) 28.71 (6.41) 0.11
WC (cm) 103.00 (10.71) 100.34 (8.91) 105.85 (10.08) 0.11 111.60 (3.13) 115.30 (11.95) 112.63 (6.33) 0.39
WHR 0.85 (0.05) 0.86 (0.04) 0.88 (0.06) 0.08 1.00 (0.03) 0.98 (0.04) 0.99 (0.03) 0.58
BMR (kcal) 1605.29 (209.01) 1523.15 (134.36) 1605.77 (142.95) 0.08 2151.81 (146.68) 2152.03 (225.11) 2222.62 (360.05) 0.77
HC (cm) 120.57 (9.80) 116.61 (8.31) 119.56 (9.27) 0.40 111.20 (2.16) 117.00 (8.63) 113.76 (6.24) 0.11
SBP (mmHg) 113.21 (18.57) 114.27 (15.64) 114.06 (14.82) 0.97 107.00 (8.36) 114.27 (28.43) 117.53 (12.87) 0.35
DBP (mmHg) 75.07 (13.11) 79.16 (10.03) 76.18 (11.84) 0.55 67.00 (9.08) 74.11 (19.46) 76.30 (10.08) 0.25
LDL-C (mg/dl) 122.82 (28.47) 124.32 (37.89) 116.66 (34.00) 0.64 125.68 (27.63) 114.48 (24.87) 122.07 (29.43) 0.56
HDL (mg/dl) 47.50 (10.25) 50.05 (7.87) 46.40 (9.37) 0.34 43.00 (6.74) 39.22 (6.87) 43.00 (6.89) 0.12
Cholesterol (mg/dl) 190.50 (33.59) 191.83 (36.94) 185.71 (36.83) 0.78 199.80 (32.87) 180.05 (27.49) 191.16 (32.40) 0.31
TG (mg/dl) 100.85 (34.30) 87.27 (34.73) 113.26 (43.26) 0.05 155.60 (53.83) 131.72 (62.35) 130.49 (70.65) 0.73
Glucose (mg/dl) 93.00 (80–121) 86.5 (70–124) 89.00 (71–122) 0.36 99.00 (81–183) 90.00 (78–193) 93.95 (77–141) 0.15
Insulin, U/ml 12.15 (4–33) 10.90 (3.10–27.30) 16.40 (3.20–4.20) 0.23 28.9 (8.9–29.9) 12.25 (4.10–30.90) 11.50 (3.30–31.10) 0.86
HOMA-IR 2.76 (0.82–8.64) 2.58 (0.60–6.13) 3.93 (0.63–8.80) 0.33 6.63 (1.78–8.05) 2.76 (0.86–8.05) 2.69 (0.64–7.37) 0.37
QUICKI 0.32 (0.03) 0.34 (0.03) 0.31 (0.02) 0.01 0.30 (0.02) 0.32 (0.02) 0.32 (0.02) 0.14
AgRP (pg/ml) 20.85 (17.10 – 90.00) 23.75 (16.50–75.00) 22.15 (12.60–65.00) 0.35 23.9 (18.40–89.00) 27.00 (17.80–63.00) 26.15 (14.70–94.00) 0.74
α-MSH (ng/L) 141.25 (105.6–680.0) 147.75 (119.1–659.0) 138.5 (98.60–624.0) 0.67 139.00 (128.5–689.0) 166.65 (116.1–620.00) 156.40 (95.10–684.00) 0.74
  1. Data are presented as mean (SD) or median (min, max)
  2. BMI: body mass index; WC: waist circumference; SBP: systolic blood pressure; DBP: diastolic blood pressure; LDL-C: low density lipoprotein cholesterol; HDL: high-density lipoprotein; TG: triglyceride; HOMA-IR: homeostasis model assessment of insulin resistance; QUICKI: quantitative insulin sensitivity check index; AgRP: agouti-related protein; α-MSH: alpha melanocyte stimulating hormone
  3. *Analysis of variance for continuous variables and χ2 test for categorical variables