Table 1 Lipid A pathways related variants identified in colistin-resistant Klebsiella pneumoniae isolates
Isolates | MIC | GenBank accession | Lipid A modification | Lipid A-Ara4N pathway (polymyxin resistance) | ||||
|---|---|---|---|---|---|---|---|---|
PagP | PhoR | ArnA_ DH/FT | UgdH | ArnC | ArnT | |||
S1 | 0.25 | JAEMVQ000000000.1 | I189F | A424_V425insSerAla | – | N354D | – | A55G |
L65F | ||||||||
S2 | 0.5 | JAEMVP000000000.1 | I189F | A424_V425insSerAla | – | V17I | S10fs | A55G |
S3 | 4 | JAEMVA000000000 | I189F | L65F | T185A | – | – | A55G |
S4 | 8 | JAEMVS000000000.1 | I189F | L65F | – | N354D | S10fs | – |
S5 | 4 | JAEMVR000000000.1 | I189F | A424_V425insSerAla | T185A | N354D | S10fs | A55G |
L65F | S18A | S10fs | ||||||
S6 | 16 | JAEMVO000000000.1 | I189F | A424_V425insSerAla | T185A | N354D | S10fs | A55G |
L65F | S18A | |||||||
S7 | 16 | JAEMVN000000000.1 | I189F | A424_V425insSerAla | L260I | A376V | S10fs | – |
M45I | D205N | N354D | ||||||
S8 | ≥ 16 | JAEMVB000000000 | I189F | L65F | – | V17I | – | A55G |