Fig. 2

Bubble plot of included low-calorie sweetener studies by intervention type, health status, and outcome category. Data points are grouped and plotted according to study population baseline health status (healthy, overweight, diabetes, mixed/other) and outcome category, further stratified by intervention. Each data point represents a single study, and is randomly scattered in each grid to maximize visualization of the bubble; the size of each bubble indicates the sample size of the corresponding study, with larger bubbles representing larger study sample size. LCS vs. Sugars: An intervention comparison between low-calorie sweeteners and sugars; LCS vs. Others: An intervention comparison between low-calorie sweeteners and non-sugar sweetener. Mixed/Other: a mixture of healthy, overweight, diabetic, or unknown baseline health characteristic study population