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Table 2 Detailed culture and sequencing results in episodes where multiple-sample sequencing added value in final determination of causative agents

From: Evaluation of multi-sample 16S ribosomal DNA sequencing for the diagnosis of postoperative bone and joint infections during antimicrobial treatment

Patient no Type of infection   Biopsy 1 Biopsy 2 Biopsy 3 Biopsy 5 Biopsy 6 Biopsy 7
4 FRI Sequencing  Klebsiella spp. Streptocuccus australis Ralstonias spp. Alcalimonas spp. Flavobacteriaceae CoNS strain 1
Culture CoNS strain 1 CoNS strain 2 Culture negative Culture negative Culture negative CoNS strain 2
5 Postoperative arthritisa Sequencing S. aureus Not detected Bacillus spp.    
Culture Culture negative Culture negative Culture negative    
11 FRI Sequencing Burkholderia cepacia Bacillus spp.     
Culture CoNS CoNS     
7 PJI Sequencing Bacilllus spp. S. aureus + Bacillus spp. S. aureus + Bacillus spp. S. aureus + Bacillus spp.   
Culture Culture negative Culture negative Culture negative Culture negative   
25 FRI Sequencing Klebsiella spp. Micrococcus luteus     
Culture Culture negative Culture negative     
  1. S. aureus Staphylococcus aureus; Spp. Species; CoNs coagulase negative staphylococci; FRI fracture related infection; PJI prosthetic joint infection
  2. aAfter cruciate ligament reconstruction