Fig. 3

ORF1p and STING protein levels are higher in older participants, and ORF1p is higher in SX versus CTL in older participants. ORF1p expression with representative image (panel a) and STING protein expression with representative image (panel b). All variables in OA patients are presented in the surgical (SX) and control (CTL) thighs as fold-change from the young comparator group (Y). Different letters above bars indicate a significant difference between groups (p < 0.05), and all data are presented as mean ± standard deviation values. Notably, the right inset images are representative of one older participant (SX and CTL leg) and a younger participant. Ponceau S images are also provided to show protein loading did not differ between lanes