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Table 1 Osteoblasts gene expression and alkaline phosphatase activity after treatment with non-osteoporotic and osteoporotic T cells exosomes

From: The effect of osteoporotic and non-osteoporotic individuals’ T cell-derived exosomes on osteoblast cells’ bone remodeling related genes expression and alkaline phosphatase activity

Target G1
mean±SD
(n = 25)
G2 mean±SD
(n = 21)
G3
mean±SD
(n = 25)
P value
G1 vs G2 G1 vs G3 G2 vs G3
Gene expression level
 RUNX2 1.007±0.04826 1.211±0.2259 0.772±0.1727 0.0002 <0.0001 <0.0001
 Type-I collagen 1.005±0.05339 1.266±0.4215 0.7472±0.2469 0.0054 0.0040 <0.0001
 Osteopontin 1.01±0.06045 1.465±0.5981 0.7084±0.1989 0.0001 0.0084 <0.0001
 Osteocalcin 1.000±0.06301 1.408±0.4706 0.666±0.3378 0.0002 0.0016 <0.0001
 ALP 1.000±0.08517 1.276±0.4766 0.9390±0.2215 NS NS 0.0205
Alkaline phosphatase (ALP) activity
ALP (U/L) 77.56±20.08 93.68±30.30 70.10±18.71 NS NS 0.0039
  1. Data are presented as mean±SD
  2. G1 osteoblasts without treatment, G2 osteoblasts treated with non-osteoporotic individuals T cells exosomes, G3 osteoblasts treated with osteoporotic individuals T cells exosomes, ALP alkaline phosphatase
  3. p<0.05 was considered as statistically significant