The effect of osteoporotic and non-osteoporotic individuals’ T cell-derived exosomes on osteoblast cells’ bone remodeling related genes expression and alkaline phosphatase activity

Table 1 Osteoblasts gene expression and alkaline phosphatase activity after treatment with non-osteoporotic and osteoporotic T cells exosomes

Target	G1 mean±SD (n = 25)	G2 mean±SD (n = 21)	G3 mean±SD (n = 25)	P value
Target	G1 mean±SD (n = 25)	G2 mean±SD (n = 21)	G3 mean±SD (n = 25)	G1 vs G2	G1 vs G3	G2 vs G3
Gene expression level
RUNX2	1.007±0.04826	1.211±0.2259	0.772±0.1727	0.0002	<0.0001	<0.0001
Type-I collagen	1.005±0.05339	1.266±0.4215	0.7472±0.2469	0.0054	0.0040	<0.0001
Osteopontin	1.01±0.06045	1.465±0.5981	0.7084±0.1989	0.0001	0.0084	<0.0001
Osteocalcin	1.000±0.06301	1.408±0.4706	0.666±0.3378	0.0002	0.0016	<0.0001
ALP	1.000±0.08517	1.276±0.4766	0.9390±0.2215	NS	NS	0.0205
Alkaline phosphatase (ALP) activity
ALP (U/L)	77.56±20.08	93.68±30.30	70.10±18.71	NS	NS	0.0039

Data are presented as mean±SD
G1 osteoblasts without treatment, G2 osteoblasts treated with non-osteoporotic individuals T cells exosomes, G3 osteoblasts treated with osteoporotic individuals T cells exosomes, ALP alkaline phosphatase
p<0.05 was considered as statistically significant

ISSN: 1756-0500