BMC Research Notes

Table 1 K_i values (nM) of reference standards at male and female rat adenosine A₁ and A_2A receptors

From: On the basis of sex: male vs. female rat adenosine A₁/A_2A receptor affinity

Reference standard	K_i value ± SEM (nM)^a				Selectivity index
Reference standard	Male rA₁vs. 0.1 nM [³H]DPCPX	Female rA₁vs. 0.1 nM [³H]DPCPX	Male rA_2Avs. 4 nM [³H]NECA	Female rA_2Avs. 4 nM [³H]NECA	Male rA_2AK_i/rA₁K_i	Female rA_2AK_i/rA₁K_i
CPA	6.5 ± 0.4^a 5 [36] 6 [37, 38] 7 [39] 8 [40] 10 [41, 42] 15 [43]	6.4 ± 0.7^a	858 ± 155^a 163 [39] 331 [43] 400 [38] 557 [36]	852 ± 175^a	132	133
Caffeine	52 800 ± 7 400^a 18 800 [44] 26 000 [45] 41 000 [10] 43 900 [46] 55 000 [47]	38 000 ± 5 220^a	18 637 ± 4 331^a 22 000 [45] 32 500 [44] 43 000 [10]	21 947 ± 5 143^a	0.4	0.6
DPCPX	0.5 ± 0.1^a 0.4 [48] 0.5 [43, 49]	0.5 ± 0.03^a	149 ± 23^a 157 [44] 340 [51] 530 [43] 545 [39]	135 ± 29^a	298	270
Istradefylline	125 ± 6^a 150 [50] 192 [38] 230 [44]	169 ± 10^a	3.3 ± 0.9^a 1 [38] 2 [50, 52] 5 [44] 8 [46] 11 [41]	2.4 ± 0.4^a	0.03	0.01

^aInhibition constant (K_i, nM) value is presented as the mean ± standard error of the mean (SEM), radioligand binding assays performed in triplicate. Values without SEM are taken from the literature [10, 36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52]

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