Table 3 Types of cancers in close relatives of patients with hereditary breast cancer in relation to the gene-specific VUS

APC

c.1564 A > G

Esophageal

Melanoma

Thyroid (2)

ATM

c.7502 A > G

c.7502 A > G

Colorectal

Oral

Breast

Breast

Colorectal

Leukemia

BRCA1

c.3392 A > G

Breast

Leukemia

Oral

Cervical

BRCA2

c.784G > A

c.2488 A > G

c.6231G > C

c.521G > A

c.8417 C > T

Breast

Ovarian

N/A

N/A

Breast (3)

Leukemia

Endometrial

BRIP1

c.3103 C > T

Colorectal

CDKN2A

c.377 A > G

Breast

Breast

CHEK2

c.60G > T

c.1501G > A

Breast (3)

Breast

FANCI

c.3179T > C

Breast

MET

c.840G > T

Breast (2)

Breast

Breast

STK11

c.355 A > G

Breast (2)

colon

NF2

c.1522G > A

Testicular