Table 2 Antimicrobial sensitivity and resistance profile of Gram-negative organisms isolated from wound and burn infections
Antibiotic | P. aeruginosa (N = 48) | Klebsiella spp. (N = 14) | Proteus spp. (N = 12) | E. coli (N = 8) | P value* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S% | I (%) | R% | S% | I (%) | R% | S% | I (%) | R% | S% | I (%) | R% | ||
Chloramphenicol | 21 (43.8%) | 10 (20.8) | 17 (35.4%) | 6 (42.9%) | 2 (14.3) | 6 (42.9%) | 8 (66.7%) | 3 (25) | 1 (8.3%) | 5 (62.5%) | 0 (0) | 3 (37.5%) | 0.262 |
Tigycyclin | 17 (35.4%) | 18 (37.5) | 13 (27.1%) | 1 (7.1%) | 9 (64.3) | 4 (28.6%) | 4 (33.3%) | 8 (66.7) | 0 (0%) | 2 (25%) | 6 (75) | 0 (0%) | 0.186 |
Gentamycin | 29 (60.4%) | 3 (6.3) | 16 (33.3%) | 11 (78.6) | 1 (7.1) | 2 (14.3%) | 6 (50%) | 1 (8.3) | 5 (41.7%) | 4 (50%) | 0 (0) | 4 (50%) | 0.318 |
Levofloxacin | 8 (16.7%) | 0 (0) | 40 (83.3%) | 9 (64.3%) | 1 (7.1) | 4 (28.6%) | 7 (58.3%) | 1 (8.3) | 4 (33.3%) | 5 (62.5) | 1 (12.5) | 2 (25%) | < 0.0001 |
Ciprofloxacin | 38 (79.2%) | 2 (4.2) | 8 (16.7%) | 6 (42.9%) | 4 (28.6) | 4 (28.6%) | 7 (58.3%) | 1 (8.3) | 4 (33.3%) | 2 (25%) | 2 (25) | 4 (50%) | 0.042 |
Ampicillin / Sulbactam | 4 (8.3%) | 8 (16.7) | 36 (75%) | 1 (7.1%) | 6 (42.9) | 7 (50%) | 0 (0%) | 0 (0) | 12 (100%) | 0 (0%) | 1 (12.5) | 7 (87.5%) | 0.532 |
Amoxicillin/ Clavulanic | 11 (23%) | 5 (10.4) | 32 (66.7%) | 3 (21.4%) | 4 (28.6) | 7 (50%) | 0 (0%) | 6 (50) | 6 (50%) | 0 (0%) | 5 (62.5) | 3 (37.5%) | 0.189 |
Ticracillin /tazobactam | 15 (31.3%) | 15 (31.3) | 18 (37.5%) | 2 (14.3%) | 5 (35.7) | 7 (50%) | 0 (0%) | 6 (50) | 6 (50%) | 4 (50%) | 1 (12.5) | 3 (37.5%) | 0.090 |
Cefuroxime | 9 (18.8%) | 9 (18.8) | 30 (62.5’%) | 3 (21.4%) | 2 (14.3) | 9 (64.3%) | 2 (16.7%) | 3 (25) | 7 (58.3%) | 0 (0%) | 0 (0) | 8 (100%) | 0.497 |
Cefazolin | 0 (0%) | 0 (0) | 48 (100%) | 0 (0%) | 0 (0) | 14 (100%) | 0 (0%) | 0 (0) | 12 (100%) | 0 (0%) | 0 (0) | 8 (100%) | N/A |
Ceftazidime | 6 (12.5%) | 7 (14.6) | 35 (73%) | 2 (14.3%) | 0 (0) | 12 (85.%) | 0 (0%) | 1 (8.3) | 11 (91.7) | 2 (25%) | 0 (0) | 6 (75%) | 0.445 |
Imipineme | 24 (50%) | 8 (16.7) | 16 (33.3%) | 7 (50%) | 2 (14.3) | 5 (35.%) | 1 (8.3%) | 7 (58.3) | 4 (33.3%) | 4 (50%) | 1 (12.5) | 3 (37.5%) | 0.472 |
Trimethoprim/ sulfamethoxazole | 19 (39.6%) | 8 (16.7) | 21 (43.8%) | 11 (78.6) | 0 (0) | 3 (21.%) | 7 (58.3%) | 0 (0) | 5 (41.7%) | 2 (25%) | 0 (0) | 6 (75%) | 0.053 |