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Table 3 Association of each log-transformed baseline biomarker levels with presence of subsequent coronary plaque. Univariable and various multivariable models including sensitivity analyses are shown. Results are odds ratios (OR) and 95% confidence intervals (CI) per one-unit difference in log-transformed biomarker level

From: Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda

Log-transformed biomarker§

Univariable

Multivariable adjusted†

Sensitivity – ASCVD‡

Sensitivity – Imputation†*

Sensitivity – Imputation ASCVD‡*

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

GDF-15

0.86 (0.47–1.47)

0.59

1.15 (0.46–2.85)

0.76

1.31 (0.55–3.11)

0.54

1.58 (0.74–3.38)

0.23

1.66 (0.81–3.38)

0.16

Galectin-3

2.67 (0.61–13.4)

0.22

3.49 (0.48–29.5)

0.23

3.33 (0.61–21.8)

0.19

4.6 (0.8–26.4)

0.09

4.86 (0.96–24.5)

0.06

ST-2

1.87 (0.58–6.26)

0.30

2.03 (0.46–8.98)

0.34

1.29 (0.35–4.88)

0.70

2.59 (0.76–8.82)

0.13

2.2 (0.75–6.46)

0.15

sFLT-1

0.92 (0.11–7.73)

0.94

0.77 (0.06–9.14)

0.84

0.75 (0.07–7.94)

0.81

2.19 (0.26–18.7)

0.47

1.38 (0.17-11)

0.76

Cystatin C

5.13 (0.62–46.7)

0.13

8.26 (0.45–182)

0.16

5.16 (0.35–91.8)

0.25

12.61 (1.34–119)

0.03

6.8 (0.75–61.6)

0.087

NT-proBNP

1.97 (1.21–3.36)

0.006*

2.71 (1.39–5.95)

0.006*

2.12 (1.2–4.06)

0.015

2.12 (1.33–3.39)

0.002*

1.77 (1.19–2.63)

0.005*

  1. § GDF-15, growth differentiation factor 15; ST-2, suppression of tumorogenicity-2; sFLT-1, soluble fms-like tyrosine kinase-1; NT-proBNP, N-terminal pro-brain natriuretic peptide
  2. † Adjusted for age, sex, HIV, DM, HTN, high TC, past or current smoking, abdominal obesity, CKD
  3. ‡ Adjusted for ASCVD risk category, HIV, abdominal obesity, and CKD
  4. * Models were fitted to the baseline cohort (n = 200) with multiple imputation applied to missing year 2 coronary CT angiography data