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Table 1 The effect of formononetin (FMN) on nitric oxide (NO) generation and infectivity rate in J774-A1 macrophages cells in comparison with the control groups. IFN-γ: gamma interferon; LPS: Lipopolysaccharide; MA: meglumine antimoniate. Mean ± SD

From: Leishmanicidal and immunomodulatory activities of the formononetin (a natural isoflavone) against Leishmania tropica

Material

NO production (nM)

Infectivity rate

% of infected macrophages

% of reduction

¼ IC50

3.11 ± 0.47

74.3 ± 4.16

8.9

1/3 IC50

4.24 ± 0.85*

53.4 ± 3.88

34.5

1/2 IC50

12.3 ± 1.42*

28.6 ± 2.51

64.9*

Non-treated

2.49 ± 0.31

81.6 ± 1.42

-

IFN-γ + LPS

30.24 ± 4.45

-

 

-

MA

-

32.3 ± 3.21

 

-

  1. * p < 0.001
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BMC Research Notes

ISSN: 1756-0500

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