Fig. 2

Distribution of Trp53 and Kras mutations in mouse mammary gland tumor tissue. Tissue areas from five tissue sections separated in the Z-plane were laser capture microdissected and mutation frequencies mapped with circles. The extent to which the circle rim is filled represents the Trp53 (A) and Kras (B) mutation allele frequency in each LCM tissue sample. LCM areas that did not generate data are marked with filled grey circles. The allele frequencies were translated to a heatmap for each Z-plane tissue section for easier interpretation of distribution patterns