Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism

Table 2 Biochemical parameters, insulin resistance and thyroid function tests before and after levothyroxine treatment

Parameters		Before	After	p*
Anthropometric	Weight (Kg)	73.45± 9.33	68.25±7.77	0.001
	BMI (kg/m²)	27.13±4.27	26.81±4.18	0.028
Biochemical	Cholesterol (mg/dl)	199.79±37.61	178.10±32.25	<0.001
	Triglyceride (mg/dl)	160.41±71.86	146±61.11	0.012
	HDL-C (mg/dl)	44.31±10.56	44.31±10.59	0.954
	LDL-C (mg/dl)	123.54±30.7	107.08±26.98	<0.001
IR	FBG (mg/dl)	91.95±13.17	92.69±13.38	0.134
	Fasting insulin (mIU/l)	8.91±3.92	8.05±2.65	<0.001
	HOMA-IR	2.07±1.56	2.09±1.46	0.451
	QUICKI	0.356±0.36	0.355±0.035	0.934
TFT	TSH (µIU/ml)	47.45±3.4	2.22±1.84	<0.001
	FT4 (ng/dl)	0.8±0.19	1.20±0.44	<0.001

Data are presented as mean ± standard division. P < 0.05 was considered as statistically significant. BMI, body mass index; HDL, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FBG, fasting blood glucose; HOMA-IR, homeostatic model assessment for insulin resistance; QUICKI, quantitative insulin sensitivity check index; IR, insulin resistance; TFT, thyroid function test
*Paired samples t-test
P < 0.05 is statistically significant

ISSN: 1756-0500