Table 3 Clinical characteristics of study participants with BC. Differences of features among cases assessed by the Mann-Whitney test
From: The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients
Variables | Frequency (%) | MMP-2 | MMP-9 | MMP-11 | |
|---|---|---|---|---|---|
P-value | |||||
Grade | I-II | 24(57.1) | 0.8112 | 0.4423 | 0.4689 |
III | 18(42.9) | ||||
Total | 42(100.0) | ||||
Tumor Size | T1-T2 | 14(33.3) | 0.4828 | 0.5773 | 0.5708 |
T3_T4 | 19(45.2) | ||||
Not assessed | 9(21.5) | ||||
Total | 42(100.0) | ||||
Lymph node | Positive | 28(66.6) | 0.5421 | 0.5656 | 0.1096 |
Negative | 9(21.5) | ||||
Not assessed | 5(11.9) | ||||
Total | 42(100.0) | ||||
Histomorphological type | Ductal carcinoma | 36(85.7) | 0.6611 | 0.1112 | 0.0221 |
Others | 6(14.3) | ||||
Total | 42(100.0) | ||||
ER | Positive | 25(59.5) | 0.4164 | 0.1528 | 0.0514 |
Negative | 17(40.5) | ||||
Total | 42(100.0) | ||||
PR | Positive | 21(50.0) | 0.8813 | 0.7088 | 0.1123 |
Negative | 21(50.0) | ||||
Total | 42(100.0) | ||||
HER2 | Positive | 8(19.0) | 0.5913 | 0.7935 | 0.6910 |
Negative | 26(62.0) | ||||
Equivocal | 8(19.0) | ||||
Total | 42(100.0) | ||||
HER2 Score | IHC0 | 17(40.5) | 0.2523 | 0.3413 | 0.2499 |
IHC 1 + negative | 9(21.5) | ||||
IHC 2 + equivocal | 8(19.0) | ||||
IHC 3 + positive | 8(19.0) | ||||
Total | 42(100.0) | ||||
Ki-67 | < 20% | 20(47.6) | 0.1162 | 0.9505 | 0.6494 |
≥ 20% | 22(52.4) | ||||
Total | 42(100.0) | ||||
IHC defined BC subtypes | Luminal A | 9(21.5) | 0.0706 | 0.7768 | 0.6292 |
Luminal B | 11(26.1) | ||||
HER2 | 5(11.9) | ||||
Triple-negative BC | 9(21.5) | ||||
Not determine | 8(19.0) | ||||
Total | 42(100.0) | ||||